A slow week.  There is more concerning data regarding the use of marijuana in pregnant women, which is prevalent in pregnant teens.  And an elegant study from Peter Schmidt and David Rubinow which gives us more information regarding the etiology of PMDD and potential strategies for its management.  


Marijuana Use During Stages of Pregnancy in the United States.

Volkow ND, Han B, Compton WM, Blanco C. Ann Intern Med. 2017 Apr 18.

More pregnant than nonpregnant teens are using marijuana (14% vs. 6.5%).

Premenstrual Dysphoric Disorder Symptoms Following Ovarian Suppression: Triggered by Change in Ovarian Steroid Levels But Not Continuous Stable Levels.

Schmidt PJ, Martinez PE, Nieman LK, Koziol DE, Thompson KD, Schenkel L, Wakim PG, Rubinow DR.  Am J Psychiatry. 2017 Apr 21.

Kataja EL, Karlsson L, Huizink AC, Tolvanen M, Parsons C, Nolvi S, Karlsson H.  Pregnancy-related anxiety and depressive symptoms are associated with visuospatial working memory errors during pregnancy.

J Affect Disord. 2017 Apr 26;218:66-74.

Pregnant women with moderate to high levels of depression or anxiety symptoms had significantly more errors in visuospatial working memory/executive functioning tasks than mothers with low symptom levels.

Influences of prenatal and postnatal maternal depression on amygdala volume and microstructure in young children.

Wen DJ, Poh JS, Ni SN, Chong YS, Chen H, Kwek K, Shek LP, Gluckman PD, Fortier MV, Meaney MJ, Qiu A.  Transl Psychiatry. 2017 Apr 25;7(4):e1103.

In this study using MRI, greater prenatal maternal depressive symptoms were associated with larger right amygdala volume in girls, but not in boys. Increased postnatal maternal depressive symptoms were associated with higher right amygdala fractional anisotropy (FA) in the overall sample in girls, but not in boys.

Physical, sexual and social health factors associated with the trajectories of maternal depressive symptoms from pregnancy to 4 years postpartum.

Giallo R, Pilkington P, McDonald E, Gartland D, Woolhouse H, Brown S.  Soc Psychiatry Psychiatr Epidemiol. 2017 Apr 27.

Three distinct trajectories were identified in women from pregnancy to 4 years postpartum representing women who experienced minimal depressive symptoms (58.4%), subclinical symptoms (32.7%), and persistently high symptoms (9.0%).  Risk factors for subclinical and persistently high depressive symptoms included immigration from a non-English speaking country, not being in paid employment during pregnancy, history of childhood physical abuse, history of depressive symptoms, and partner relationship problems during pregnancy.


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