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Archive | Postpartum Psychiatric Disorders

New Study at the CWMH: Brexanolone (SAGE-547) for Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression.  SAGE-547, now called brexanolone, is a new type of antidepressant: a formulation of allopregnanolone, which is an endogenous, naturally occurring neuroactive steroid and a metabolite of progesterone.  Data from the most recent study of brexanolone was […]

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In Brief: Problem-Solving Education Intervention Reduces Risk of Postpartum Depression

  While many women are at risk for postpartum depression, we continue to struggle in providing adequate support and care to women in this setting, especially socioeconomically disadvantaged women.   In a randomized clinical trial including 230 Head Start mothers, those receiving problem-solving education (PSE) were 60% less likely to develop postpartum depression than those […]

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Psychiatric Clinics of North America: June Issue on Women’s Mental Health

In the field of reproductive psychiatry, we don’t really have any textbooks to rely on.  However, the June issue of the Psychiatric Clinics of North America is devoted to Women’s Mental Health, and it’s pretty much the most comprehensive guide on this topic. With articles from leaders in the field, it covers PMDD, medication use […]

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Lamotrigine Reduces Risk for Postpartum Relapse in Women with Bipolar Disorder

Numerous studies have demonstrated that women with histories of bipolar disorder are at high risk for postpartum illness.  Because of this increased risk for relapse during the postpartum period, we typically recommend that women with histories of bipolar disorder continue treatment with a mood stabilizer throughout the postpartum period.  Historically, lithium has been the most […]

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Pilot Study of Telephone-Delivered Interpersonal Therapy for Women with Postpartum Depression

It is clear that screening for perinatal depression substantially improves detection; however, screening alone does not appear to improve rates of treatment or outcomes.  What we find is that many, if not most, women with perinatal depression do not receive adequate care.  There appear to be many obstacles: stigma associated with mental illness, lack of […]

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Brexanolone: Related to Allopregnanolone, Effective for the Treatment of Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression.  SAGE-547, now called brexanolone, is an allosteric modulator of GABAA receptors.  This drug was initially under investigation for the treatment of refractory seizure disorders but it turned out to be a good antidepressant.  The information we […]

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Credit: Pregnant Woman from Wikimedia Commons

Register for the Postpartum Support International Annual Conference in Philadelphia

The 30th Postpartum Support International Annual Conference will be taking place in Philadelphia, Pennsylvania on July 14-15, 2017. The annual PSI conference provides an opportunity to meet, learn together, and share ideas with others involved in the field of perinatal mood and anxiety disorders (PMADs). This professional event is a unique training and networking opportunity, […]

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Perinatal Depression in Fathers: Who is At Greatest Risk?

While perinatal depression is typically considered to be a woman’s illness, a number of studies have suggested that, although men do not experience any of the dramatic physiologic or hormonal changes that go along with pregnancy and the postpartum period, new fathers may also experience perinatal depression. In a cohort study of 3523 new fathers […]

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Dietary Supplements to Prevent Postpartum Depression? Proceed with Caution

Over the last few days, there has been a lot of buzz regarding the use of a nutritional supplement to reduce risk of postpartum depression.  Quoting one of these articles:  “‘Women who take the supplement don’t get sad [in the early days of motherhood],’ said Dr. Jeffrey Meyer, co-author of a study testing this blues-banishing […]

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Synthetic Oxytocin and Its Effect on Postpartum Mood and Anxiety

Often referred to as the “hormone of love,” oxytocin plays an important role in childbirth, maternal behavior, lactation, social affiliation, and sexual pleasure.  Levels of oxytocin, a neuropeptide produced by the hypothalamus and released into the bloodstream via the pituitary gland, rise around the time of delivery.   These levels remain high after delivery, specifically increasing […]

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