The Valproic Acid Warning Clinicians Can’t Ignore: Video from Dr. Marlene Freeman
Dr. Marlene Freeman warns that valproic acid poses severe, well-established reproductive risks and should not be used by anyone who could become pregnant.
Topiramate and Risk of Major Malformations: What Clinicians and Patients Need to Know
Topiramate exposure in early pregnancy is linked to higher rates of major malformations and more specifically to increased risk of oral clefts, with risk rising at higher doses.
Can Esketamine Be Used to Prevent Postpartum Depression?
Emerging evidence suggests perioperative esketamine may reduce postpartum depression risk and improve recovery; however, information regarding long-term efficacy and optimal use is limited.
Fact Sheet: Valproic Acid (Depakote) and Pregnancy
Using valproic acid (Depakote) during pregnancy raises important safety concerns, including increased risks of congenital malformations and neurodevelopmental disorders.
Isn’t It Time for Stricter Valproic Acid Warnings for Women of Reproductive Age?
Despite FDA warnings, valproate is still prescribed to women of reproductive age, placing children at risk for birth defects and neurodevelopmental disorders.
Beyond the FDA Panel: Medical Experts Reaffirm the Safety and Essential Role of SSRIs for Perinatal Mental Health
The recent FDA expert panel focused largely on the risks of SSRIs during pregnancy; however, medical organizations and experts support the important role of SSRIs and other medications in supporting maternal mental health.
Essential Reads: Prenatal Exposure to Valproate and Risk of Neurodevelopmental Disorders in Offspring
Prenatal exposure to valproate is linked to increased risk of autism spectrum disorder, ADHD, lower IQ, and intellectual disability, especially at higher doses.
Essential Reads: Why All Women of Reproductive Age Should Take Folic Acid
Folic Acid Awareness Week (Sept 7–14, 2025) focuses on the importance of daily folic acid supplements for women to prevent birth defects, as diet alone is often insufficient.
Marlene Freeman, MD: Getting to the Truth About SSRIs and Pregnancy (Video)
The recent FDA expert panel focused largely on the risks of SSRIs during pregnancy; Dr. Freeman weighs in on the information provided in the report.
Information for Patients: How to Interpret the Recent FDA Panel on SSRIs and Pregnancy
The recent FDA expert panel focused largely on the risks of SSRIs during pregnancy but ignored or diminished the risks associated with untreated depression in the mother.Â