Dr. Lee S. Cohen, Director of the Ammon-Pinizzotto Center for Women's Mental Health at Massachusetts General Hospital, recently shared his insights on zuranolone for postpartum depression with Ob.Gyn News on December 14, 2023.
More study is needed regarding the safety of trazodone for the treatment of insomnia during pregnancy.
This study provides reassuring data on the use of mirtazapine during pregnancy, demonstrating no association between exposure and risk of major malformations or pregnancy loss.
Lithium use during pregnancy was associated with an increased risk of preterm birth and large for gestational age infants.
New findings from the National Pregnancy Registry for Atypical Antipsychotics provide reassuring data regarding the safety of prenatal exposure to lurasidone and quetiapine in a sample of well-characterized participants.
Based on this large cohort study including 990 pregnancies with first trimester exposure to atomoxetine, the researchers observed no increase in major congenital malformations overall and no statistically increased risk estimates for cardiac or limb malformations.
Although a small sample, no major malformations were observed in a prospectively followed cohort of women with first trimester exposure to buspirone.
Many women experience depression during pregnancy. What is the best way to identify these women?
Reassuring News: Neurodevelopmental Outcomes in Two-Year Olds with Prenatal Exposure to Lamotrigine (Lamictal)
These findings are encouraging and suggest that the newer AEDs, specifically lamotrigine and levetiracetam, are not associated with worse neurodevelopmental outcomes.
Essential Reads: Long-Term Neurodevelopmental Outcomes in Children with Prenatal Exposure to Antidepressants
While questions and controversies remain, the information on long-term neurodevelopmental outcomes in children prenatally exposed to antidepressants is largely reassuring.