Mass General Hospital

Harvard Medical School



Weekly Roundup for MAY 27 2016: Publications in Reproductive Psychiatry

Mirtazapine in pregnancy and lactation – A systematic review. Smit M, Dolman KM, Honig A. Eur Neuropsychopharmacol. 2016 Jan;26(1):126-35. Pregnancy outcome following maternal exposure to pregabalin may call for concern.   Winterfeld U, Merlob P, Baud D, Rousson V, et al. Neurology. 2016 May 18. REVIEWED ON OUR WEBSITE MATERNAL DEPRESSION AND CHILD OXYTOCIN RESPONSE; […]

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Post-Adoption Depression: How Common? Who is At Risk?

While we tend to think of postpartum depression (PPD) as a hormonally driven mood disorder in women, multiple studies have suggested that, although men do not experience any of the dramatic physiological or hormonal changes that go along with pregnancy, new fathers may also suffer from PPD.  There are perhaps elements of caring for a […]

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Pregabalin (Lyrica) and Pregnancy: Preliminary Data

Pregabalin (marketed in the US as Lyrica) is approved by the US Food and Drug Administration for the treatment of epilepsy, fibromyalgia, and neuropathic pain.  It is also used off-label to treat psychiatric disorders, most commonly generalized anxiety disorder.  While it is not used as frequently as other anti-epileptic drugs, we do occasionally see women […]

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Baby Belly from Wikimedia Commons

SSRIs and Pregnancy: No Risk of Cardiovascular Malformations According to UK Study

Over the last few years, several studies have suggested an increased risk of certain types of cardiovascular malformations in children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports suggested a link between cardiac septal defects and exposure to paroxetine; other, but not all, studies have also shown an elevated risk of […]

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Credit: Pregnant Woman from Wikimedia Commons

Positive Parental Engagement Protects Children from the Detrimental Effects of Prenatal Stress

  Studies in animals and humans suggest that psychological distress experienced by mothers during pregnancy is associated with later neurodevelopmental problems in their offspring.  Project Ice Storm is one such study exploring the effect of prenatal maternal stress on child cognitive functioning. In January 1998, an  ice storm hit the Canadian province of Quebec and […]

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Weekly Roundup for MAY 20 2016: Publications in Reproductive Psychiatry

Selective serotonin reuptake inhibitors and congenital heart anomalies:comparative cohort studies of women treated before and during pregnancy and their children. Petersen I, Evans SJ, Gilbert R, Marston L, Nazareth I. J Clin Psychiatry. 2016 Jan;77(1):e36-42. Factors influencing attempted and completed suicide in postnatal women: A population-based study in Taiwan. Weng SC, Chang JC, Yeh MK, […]

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By Vera Kratochvil [Public domain], via Wikimedia Commons

Maternal Depression and Its Effects on the Child:  What is the Role of Oxytocin?

There is significant literature indicating that a mother’s depression may adversely affect her young child.  Studies have demonstrated that the children of depressed mothers are more likely than the children of non-depressed mothers to exhibit developmental delays and childhood behavioral problems.  It has also been demonstrated that the children of depressed mothers are more likely […]

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Pregnancy Brain? Or a Symptom of Depression?

During pregnancy, many women complain that they feel more distractible, more forgetful or less sharp than before pregnancy. A few years ago, we reviewed a study which demonstrated that performance on tests of spatial recognition memory (SRM) were adversely affected by pregnancy. Other aspects of executive function were unaffected.   A recent study assessed working […]

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By Ragesoss - Own work, CC BY-SA 3.0,

Why You Shouldn’t Stop Taking Your Prenatal Vitamins

  It’s only been a few days since Johns Hopkins released the preliminary results of a study on folate levels and autism, and we have already received calls and emails regarding the findings.  Unfortunately the headlines in many of the news articles have been incredibly misleading.  Take for instance, “A Study Asks: Too Much Folic […]

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