Weekly Roundup for NOVEMBER 16, 2018: Recent Publications in Women’s Mental Health
Why do we need to identify and treat women with depression who experience during pregnancy? We have long known that postpartum depression can negatively affect the development of children, the large study from Tuovinen and colleagues clearly shows that depression during pregnancy can have negative effects on the child’s development, predicting lower scores on measures of developmental milestones, fine and gross motor skills, communication, problem solving, and personal/social skills. One of [...]
No Increased Risk of Autism in Children Prenatally Exposed to Commonly Used Antidepressants
Concerns regarding a link between antidepressant use during pregnancy and autism emerged when two epidemiologic studies demonstrated an association between prenatal exposure to selective serotonin reuptake inhibitor antidepressants (SSRIs) with an increased risk of autism spectrum disorders in the offspring (ASD; Croen et al 2011, Rai et al, 2013). One important limitation of these earlier studies is that parental psychiatric disorder in itself is associated with an increased risk of ASD [...]
New Study at CWMH: A Neurosteroid Intervention for Menopausal and Perimenopausal Depression
Women are twice as likely as men to have major depressive disorder (MDD) during their lifetimes, and women are particularly at risk during the menopausal transition (including perimenopause and early menopause), which can last many years. Typically starting after age 40, this period is characterized by fluctuations in hormones and various physical symptoms like hot flashes, as well as mood symptoms. Although some treatments are available, many women would like to [...]
In Brief: Being An Older Dad Associated with Worse Pregnancy Outcomes
This study is something to keep in mind when we evaluate neonatal outcomes in mothers taking psychotropic medication. We typically consider maternal, but not paternal, characteristics as factors which may affect neonatal outcomes; however, this large study published in BMJ indicates that the age of the father may also affect neonatal outcomes. Researchers examined data on 40 million live births between 2007 and 2016. After adjusting for maternal age and [...]
Weekly Roundup for NOVEMBER 9, 2018: Recent Publications in Women’s Mental Health
At this top of the list, we have a study which looked at prenatal exposure to a wide array of psychotropic medications and risk for autism spectrum disorders in the offspring. They found no association between exposure to SSRIs and risk for autism. Ruta Nonacs, MD PhD Association of Autism Spectrum Disorder With Prenatal Exposure to Medication Affecting Neurotransmitter Systems. Janecka M, Kodesh A, Levine SZ, Lusskin SI, Viktorin A, Rahman [...]
FDA Supports Intravenous Brexanolone for Postpartum Depression
In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD). SAGE-547, now called brexanolone, is an allosteric modulator of GABAA receptors. Since that time, Sage Therapeutics has conducted three randomized controlled trials, enrolling a total of 247 women diagnosed with moderate to severe postpartum depression. This week the US Food and Drug Administration (FDA) advisory panel voted unanimously in favor of approval [...]