Pregnancy Outcomes

Accumulating Data on the Reproductive Safety of Second-Generation, Atypical Antipsychotics, But Still Not Enough

In a cohort of 351 children exposed to second generation antipsychotic during pregnancy, the risk of major congenital malformations did not differ from a comparison group of non-exposed children.

Essential Reads: Modafinil and Armodafinil During Pregnancy Associated with Increased Risk of Malformations

Modafinil (brand name Provigil) and armodafinil (Nuvigil) are wake-promoting agents used to treat sleepiness due to narcolepsy, shift work sleep disorder, or obstructive sleep apnea. They are also used in other settings, often in [...]

Prenatal Exposure to Valproic Acid Linked to Increased Risk for Autism, ADHD

Prenatal exposure to valproate has been associated with an elevated risk (10%) for a broad range of congenital malformations including neural tube defects, as well as adverse neurodevelopmental sequelae, including lower IQ and developmental delays [...]

Prenatal Valproic Acid (Depakote) Exposure Increases Risk for Neurodevelopmental Disorders

While we have considerable information regarding the teratogenic risk associated with prenatal exposure to various antiepileptic drugs (AEDs), we have considerably less information on the impact of exposure to AEDs on behavioral outcomes in [...]

Maternal Anxiety and Adverse Perinatal Outcomes: Why We Need to Screen Women for Anxiety During Pregnancy

When providing information to patients regarding the use of medications during pregnancy, one key element of the decision-making process is an appraisal of the risks associated with untreated psychiatric illness in the mother.  While there [...]

Lithium and Anticonvulsant Mood Stabilizers: No Higher Risk for Adverse Pregnancy Outcomes

For women with bipolar disorder, choosing whether to maintain or discontinue treatment with a mood stabilizer during pregnancy is challenging.  This is a process which requires careful and thoughtful consideration, weighing the risk of adverse [...]

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