Pregnancy Outcomes

Prenatal Exposure to Valproic Acid Linked to Increased Risk for Autism, ADHD

Prenatal exposure to valproate has been associated with an elevated risk (10%) for a broad range of congenital malformations including neural tube defects, as well as adverse neurodevelopmental sequelae, including lower IQ and developmental delays [...]

Prenatal Valproic Acid (Depakote) Exposure Increases Risk for Neurodevelopmental Disorders

While we have considerable information regarding the teratogenic risk associated with prenatal exposure to various antiepileptic drugs (AEDs), we have considerably less information on the impact of exposure to AEDs on behavioral outcomes in [...]

Modafinil and Armodafinil During Pregnancy: Data to Suggest Increased Risk of Malformations

As soon as we published this article on the use of modafinil during pregnancy, another study was published which included data on the reproductive safety of modafinil and armodafinil from the US Provigil/Nuvigil Pregnancy [...]

Maternal Anxiety and Adverse Perinatal Outcomes: Why We Need to Screen Women for Anxiety During Pregnancy

When providing information to patients regarding the use of medications during pregnancy, one key element of the decision-making process is an appraisal of the risks associated with untreated psychiatric illness in the mother.  While there [...]

Lithium and Anticonvulsant Mood Stabilizers: No Higher Risk for Adverse Pregnancy Outcomes

For women with bipolar disorder, choosing whether to maintain or discontinue treatment with a mood stabilizer during pregnancy is challenging.  This is a process which requires careful and thoughtful consideration, weighing the risk of adverse [...]

Anti-Epileptic Drugs in Reproductive Age Women: Valproic Acid and Topiramate Commonly Used

There have long been concerns regarding the safety of the anticonvulsant valproic acid (Depakote) during pregnancy.  Back in 2009, the American Academy of Neurology and American Epilepsy Society recommended against the use of valproic acid [...]

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