Osborne and colleagues explore the effects of maternal depression during pregnancy on the child, noting that elevated measures of inflammation and cortisol levels in the mother have an impact on stress reactivity and behavior in the child after birth.  In order to better able detect eating disorders during pregnancy, Bannatyne and colleagues identify signs and symptoms of disordered eating specific to pregnancy.


Ruta Nonacs, MD PhD

Antenatal depression programs cortisol stress reactivity in offspring through increased maternal inflammation and cortisol in pregnancy: The Psychiatry Research and Motherhood – Depression (PRAM-D) Study.

Osborne S, Biaggi A, Chua TE, Du Preez A, Hazelgrove K, Nikkheslat N, Previti G, Zunszain PA, Conroy S, Pariante CM.  Psychoneuroendocrinology. 2018 Jul 13. Free Article

Compared to healthy controls, women with MDD in pregnancy had raised levels of several different inflammatory biomarkers and raised diurnal cortisol secretion.  Women with MDD had neonates with suboptimal neurobehavioral function in four out of five NBAS clusters measured and increased cortisol response to stress at one year of age.  Levels of maternal inflammatory biomarkers and cortisol were correlated with infant stress response, suggesting a mechanistic link.

Signs and symptoms of disordered eating in pregnancy: a Delphi consensus study.

Bannatyne AJ, Hughes R, Stapleton P, Watt B, MacKenzie-Shalders K.  BMC Pregnancy Childbirth. 2018 Jun 26;18(1):262. Free Article

A three-round modified Delphi method was used to reach a consensus regarding the clinical features of disordered eating during pregnancy.  Using a consensus approach, a number of clinical features were identified which could help practitioners delineate disordered eating symptomatically from normative pregnancy experiences.

Consensus on the assessment of disordered eating in pregnancy: an international Delphi study.

Bannatyne AJ, Hughes R, Stapleton P, Watt B, MacKenzie-Shalders K.  Arch Womens Ment Health. 2018 Aug;21(4):383-390.

Recurrence of bipolar disorder during pregnancy: a systematic review.

Salim M, Sharma V, Anderson KK.  Arch Womens Ment Health. 2018 Aug;21(4):475-479.

This review included studies (n?=?11), observing a wide variation in the reported proportions of pregnant women with bipolar disorder who experienced a recurrence (median?=?24%, range?=?4-73%).

Prevalence of Depression Among Fathers at the Pediatric Well-Child Care Visit.

Cheng ER, Downs SM, Carroll AE.  JAMA Pediatr. 2018 Jul 23.

Out of 806 visits where fathers completed depression screening questionnaires, a total of 36 fathers screened positive for depression, which was similar to the proportion of mothers who screened positive.  However, only about a third of fathers were present at pediatric visits.

Postnatal depressive symptoms in women with and without antenatal depressive symptoms: results from a prospective cohort study.

Pampaka D, Papatheodorou SI, AlSeaidan M, Al Wotayan R, Wright RJ, Buring JE, Dockery DW, Christophi CA.  Arch Womens Ment Health. 2018 Jul 4.

Overall, antenatal depressive symptoms were the strongest predictor of depressive symptoms. Among women without antenatal depressive symptoms, women who had lower income, experienced other problems in pregnancy such as perceived stress, PTSD symptoms and social isolation, and those who delivered a boy were at higher risk for PPD.

Physical activity in pregnancy and postpartum depressive symptoms in a multiethnic cohort.

Shakeel N, Richardsen KR, Martinsen EW, Eberhard-Gran M, Slinning K, Jenum AK.  J Affect Disord. 2018 Aug 15;236:93-100.

Women who accumulated ?150 moderate-to-vigorous physical activity (MVPA) minutes/week had significantly lower risk for PPD (OR?=?0.2, 95% CI: 0.06-0.90) than women who did not accumulate any minutes/week of MVPA, adjusted for ethnic minority background.

Omega-3 polyunsaturated fatty acid supplementation in prevention and treatment of maternal depression: Putative mechanism and recommendation.

Hsu MC, Tung CY, Chen HE.  J Affect Disord. 2018 Oct 1;238:47-61.

Based on a review of the medial literature, the authors conclude that dietary supplementation with omega-3 fatty acids rich in EPA during pregnancy or postpartum reduces some symptoms associated with depression. Long-term DHA supplementation starting prior to pregnancy ih healthy women can also reduce the risk of PPD.  However, there are studies which show no beneficial effects of omega-3 fatty acids, and the data might not be generalizable to women with histories of depression.

The comorbidity of low back pelvic pain and risk of depression and anxiety in pregnancy in primiparous women.

Virgara R, Maher C, Van Kessel G.  BMC Pregnancy Childbirth. 2018 Jul 4;18(1):288.  Free Article

Women with low back and pelvic pain (LBPP) were 13 times more likely to experience depression/anxiety.  Women with depression/anxiety were 2.2 times more likely to have LBPP, and among women who reported LBPP, the level of disability experienced was significantly higher in women who reported depression/anxiety.

The dynamic serotonin system of the maternal brain.

Lonstein JS.  Arch Womens Ment Health. 2018 Jul 21.

Activity based group therapy reduces maternal anxiety in the Neonatal Intensive Care Unit – a prospective cohort study.

John HB, Philip RM, Santhanam S, Padankatti SM, Sebastian T, Balan I, Rajapandian E.  Early Hum Dev. 2018 Jul 19;123:17-21.

In the group of 17 women participating in this intervention, there was a significant reduction in the post-test anxiety scores as compared to pre-test scores and were significantly lower than scores in the control group.

Stigma in the context of pregnancy termination after diagnosis of fetal anomaly: associations with grief, trauma, and depression.

Hanschmidt F, Treml J, Klingner J, Stepan H, Kersting A.  Arch Womens Ment Health. 2018 Aug;21(4):391-399.

The proportion of participants reporting the following was 17.6% for grief, 18.9% for posttraumatic stress, and 10.8% for depression. Higher levels of current internalized stigma were related to higher levels of grief, trauma, and depression.

Mother’s attachment history and antenatal attachment to the second baby: the moderating role of parenting efficacy in raising the firstborn child.

Chen BB, Xu Y.  Arch Womens Ment Health. 2018 Aug;21(4):403-409.

Longitudinal trajectories of antidepressant use in pregnancy and the postnatal period.

Bandoli G, Kuo GM, Sugathan R, Chambers CD, Rolland M, Palmsten K.  Arch Womens Ment Health. 2018 Aug;21(4):411-419.

The highest trajectory group of antidepressant use in pregnancy was associated with a modest reduction in birth weight but not with gestational age at delivery.

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