Every week we review the most recent publications in women’s mental health, covering topics related to premenstrual symptoms, perinatal mood and anxiety disorders, use of medications in pregnant and breastfeeding women, perinatal substance use, and menopausal mental health. 

For more detailed descriptions of many of these topics, you can sign up to receive our weekly CWMH NEWSLETTER which comes out every Thursday.  

And don’t forget to visit ESSENTIAL READS – a curated selection of up-to-date and clinically relevant articles in women’s mental health.

Ruta Nonacs, MD PhD



No articles this week



The complex relationship between infertility and psychological distress (Review).

Simionescu G, Doroftei B, Maftei R, Obreja BE, Anton E, Grab D, Ilea C, Anton C.  Exp Ther Med. 2021 Apr;21(4):306. Free article. 



Maternal depressive and anxiety symptoms before and during the COVID-19 pandemic in Canada: a longitudinal analysis.

Racine N, Hetherington E, McArthur BA, McDonald S, Edwards S, Tough S, Madigan S.  Lancet Psychiatry. 2021 Mar 24:

Compared with previous estimates, the prevalence of maternal depression and anxiety among mothers in a Canadian cohort increased during the COVID-19 pandemic.  Larger increases in depression and anxiety symptoms were observed for women who had income disruptions, difficulty balancing home schooling with work responsibilities, and those with difficulty obtaining childcare.

 Pregnancy during the pandemic: The impact of COVID-19-related stress on risk for prenatal depression.

King LS, Feddoes DE, Kirshenbaum JS, Humphreys KL, Gotlib IH.  Psychol Med. 2021 Mar 30:1-32.

mHealth Mindfulness Intervention for Women with Moderate-to-Moderately-Severe Antenatal Depressive Symptoms: a Pilot Study Within an Integrated Health Care System.

Kubo A, Aghaee S, Kurtovich EM, Nkemere L, Quesenberry CP Jr, McGinnis MK, Avalos LA.  Mindfulness (N Y). 2021 Mar 11:1-11. Free article.

This study observed significant improvements in scores for depression symptoms, perceived stress, sleep disturbance, and mindfulness.

Screening for perinatal anxiety.

Mazzoni SE, Bott NL, Camille Hoffman M.  Am J Obstet Gynecol. 2021 Mar 8:

A positive EPDS alone was correlated with a positive GAD-7. In the presence of a negative EPDS screen, using a score of 5 or greater on the three anxiety-specific EPDS questions may be helpful in identifying women who could benefit from further anxiety screening and treatment.

Regional cerebral activity abnormality in pregnant women with antenatal depression.

Cheng B, Wang X, Zhou Y, Li J, Zhao Y, Xia S, Zuo Y, Meng Y, Deng W, Guo Y, Wang S.  J Affect Disord. 2020 Sep 1;274:381-388.

In women with antenatal depression, aberrations in cerebral activity were observed mainly located within the prefrontal-limbic circuit.

Effectiveness of peer support intervention on perinatal depression: A systematic review and meta-analysis.

Huang R, Yan C, Tian Y, Lei B, Yang D, Liu D, Lei J.  J Affect Disord. 2020 Nov 1;276:788-796. 

Peer support interventions reduced mean depression scores (-0.37, 95% CI -0.66 to -0.08) and reduced risk of depression (RR = 0.69, 95% CI 0.49-0.96).

Antenatal psychological intervention for universal prevention of antenatal and postnatal depression: A systematic review and meta-analysis.

Yasuma N, Narita Z, Sasaki N, Obikane E, Sekiya J, Inagawa T, Nakajima A, Yamada Y, Yamazaki R, Matsunaga A, Saito T, Watanabe K, Imamura K, Kawakami N, Nishi D.  J Affect Disord. 2020 Aug 1;273:231-239. 

Psychological intervention in an antenatal period could be effective for universal prevention of both antenatal and postnatal depression.



Contextualizing Potential Risks of Medications in Pregnancy for the Newborn-the Case of Ondansetron.

Huybrechts KF, Hernández-Díaz S, Bateman BT.  JAMA Pediatr. 2020 Aug 1;174(8):747-748. 



The effect of ketamine on preventing postpartum depression.

Alipoor M, Loripoor M, Kazemi M, Farahbakhsh F, Sarkoohi A.

J Med Life. 2021 Jan-Mar;14(1):87-92. Free article.

Using ketamine in the induction of general anesthesia could be effective in preventing postpartum depression.

Postpartum psychiatric readmissions: A nationwide study in women with and without epilepsy.

Isseroff D, Lin JY, Kwon CS, Agarwal P, Mazumdar M, Dhamoon M, Howell EA, Jetté N.  Epilepsia. 2021 Mar 10.

The odds ratio for psychiatric hospitalization was 10.13 (95% confidence interval = 5.48-18.72) in those with epilepsy compared to those without. 



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No articles this week



Canonical TGF-? signaling regulates the relationship between prenatal maternal depression and amygdala development in early life.

Qiu A, Zhang H, Wang C, Chong YS, Shek LP, Gluckman PD, Meaney MJ, Fortier MV, Wu Y.  Transl Psychiatry. 2021 Mar 15;11(1):170. Free article.

Longitudinal studies examining the impact of prenatal and subsequent episodes of maternal depression on offspring antisocial behaviour.

Morgan JE, Channon S, Penny H, Waters CS.  Eur Child Adolesc Psychiatry. 2021 Jan;30(1):5-40. Free article.

Studying the Intergenerational Transmission of Risk for Depression: Current Status and Future Directions.

Gotlib IH, Goodman SH, Humphreys KL.  Curr Dir Psychol Sci. 2020 Apr 1;29(2):174-179. Free article.

Female infants are more susceptible to the effects of maternal antenatal depression; findings from the Pelotas (Brazil) Birth Cohort Study.

Netsi E, Coll CVN, Stein A, Silveira MF, Bertoldi AD, Bassani DG, Wehrmeister FC, Domingues MR.  J Affect Disord. 2020 Apr 15;267:315-324. Free article.

This study observed an increased risk of being SGA for female offspring of women with moderate and severe depression.

Maternal perinatal mental health and infant and toddler neurodevelopment – Evidence from low and middle-income countries. A systematic review.

Burger M, Hoosain M, Einspieler C, Unger M, Niehaus D.  J Affect Disord. 2020 May 1;268:158-172. 



No articles this week



No articles this week

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