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Tag Archives | SSRIs

Ovarian Suppression for PMDD: New Study Suggests Long-Term Effectiveness and Tolerability

  PMDD or premenstrual dysphoric disorder has always been a bit of mystery.  We explain that PMDD is triggered by changes in reproductive hormone levels, but when you look at hormone levels in women with PMDD, they do not differ significantly from the hormone levels of women without PMDD.  Another question is why some women […]

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What Causes Poor Neonatal Adaptation in Antidepressant-Exposed Infants?

It was back in 2005 when we first reported on studies which demonstrated an increased risk of “poor neonatal adaptation” in infants with prenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants in late pregnancy.  Since that time, reports consistently indicate that about 25%-30% of infants exposed to SSRIs late in pregnancy manifest symptoms of […]

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Combining Tamoxifen with Antidepressants: What You Need to Know

Two thirds of all breast cancer tumors are known to have receptors that respond to hormones; that is they can grow in response to estrogen. Tamoxifen is a medication which selectively blocks estrogen receptors on breast cancer tumors and, in this fashion, reduces the risk of recurrence by half in women with estrogen receptor-positive breast […]

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Response to the New York Times Article on SSRIs and Pregnancy: Moving Toward a More Balanced View of Risk

We have received many emails and calls from colleagues and patients regarding the recent article on the safety of SSRI use during pregnancy published in the New York Times.  In this article, health writer Roni Caryn Rabin, detailed the risks associated with the use of antidepressants during pregnancy.

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Low Dose Paroxetine Improves Sleep in Postmenopausal Symptoms

Last year, the FDA approved the first non-hormonal treatment for hot flashes – a 7.5-mg formulation of the selective serotonin reuptake inhibitor (SSRI) paroxetine which was marketed under the name of Brisdelle. A new study suggests that low dose paroxetine (7.5 mg) not only helps with vasomotor symptoms, it can also improve sleep. In a […]

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Antidepressants and Weight Gain: Which Ones are the Worst Offenders?

Many women are understandably concerned about the risk of weight gain associated with antidepressants. It is difficult to advise them as to which antidepressants are less or more likely to cause weight gain, as there are no head-to-head comparisons. In a recent electronic health record study including data from 22,610 individuals, 19,244 of which were […]

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New Research from the CWMH: Venlafaxine As Effective As Estradiol for Hot Flashes

Various selective serotonin reuptake inhibitors (SSRIs), including citalopram (Celexa), escitalopram (Lexapro) and paroxetine (Paxil), have been shown to be effective for the treatment of menopausal vasomotor symptoms (VMS). Other studies have supported the efficacy of the serotonin–norepinephrine reuptake inhibitors (SNRIs) duloxetine (Cymbalta) and venlafaxine (Effexor). The FDA recently approved a 7.5-mg formulation of paroxetine (marketed as Brisdelle) as the first non-hormonal treatment of hot flashes.

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Good News: New Studies Show No Association Between Antidepressants and Risk of Autism

Two recent epidemiologic studies have demonstrated an association between prenatal exposure to selective serotonin reuptake inhibitor antidepressants (SSRIs) with autism spectrum disorders (ASD; Croen et al 2011, Rai et al, 2013).  One important imitation of these two studies is that parental psychiatric disorder in itself is associated with an increased risk of ASD in the offspring, and these studies could not distinguish between the effects of drug exposure and the consequences of the underlying maternal psychiatric illness.  Two new studies shed light on the association between prenatal antidepressant exposure and risk of autism spectrum disorder in the offspring.

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