Mass General Hospital

Harvard Medical School

Tag Archives | PMAD

Brexanolone: Related to Allopregnanolone, Effective for the Treatment of Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression.  SAGE-547, now called brexanolone, is an allosteric modulator of GABAA receptors.  This drug was initially under investigation for the treatment of refractory seizure disorders but it turned out to be a good antidepressant.  The information we […]

Continue Reading · 0

Postpartum Progress: An Update and Other Resources

We were saddened to hear that Postpartum Progress, Inc. is in the process of shutting down.  Since its inception in 2004, Postpartum Progress has been an important resource for women with perinatal mood and anxiety disorders.  This organization — and all of the women behind it — have made such vital contributions in terms of […]

Continue Reading · 0

Postpartum Specific Anxiety Scale: A New Instrument for Assessing Postpartum Anxiety

  Several studies suggest that postpartum anxiety is relatively common among postpartum women and may even be more common than depression.  Emerging evidence also suggests that a large number of postpartum women who do not meet diagnostic criteria for a specific anxiety disorder yet experience a clinically significant anxiety symptoms which are distinct from anxiety […]

Continue Reading · 2

How Can We Screen for Perinatal Depression in the Developing World?

While perinatal mood and anxiety disorders (PMAD) have a global footprint, the majority of research related to this group of illnesses has come largely from more affluent, Westernized countries.  Similarly, the tools used to detect and screen for PMADs were developed and tested in these Westernized countries.   The instrument most commonly used to detect […]

Continue Reading · 1

Is BDNF a Biomarker for Depression During Pregnancy and the Postpartum Period?

Brain-derived neurotrophic factor (BDNF) is a growth factor which acts on neurons in both the central and peripheral nervous systems, promoting the survival of neurons and promoting the growth and differentiation of new neurons and synapses.  In the brain, it is most active in the hippocampus, cortex, and basal forebrain—areas important  to learning, memory, and […]

Continue Reading · 0

Sleep Problems Common During Pregnancy, Associated with Depression

While we tend to think of sleep deprivation as a postpartum issue, a recent study from Finland indicates that sleep problems are relatively common during pregnancy, for both mothers and fathers. This study included 1667 mothers and 1498 fathers.  The researchers evaluated the core symptoms of insomnia (sleep onset problems, nocturnal awakenings, too-early awakenings, and […]

Continue Reading · 0

New Legislation to Support Maternal Mental Health

Some good news for women with perinatal mood and anxiety disorders… Today, the U.S. House of Representatives passed the Bringing Postpartum Depression Out of the Shadows Act  to provide federal grants to develop and maintain programs for screening and treatment of postpartum depression. This bill, introduced by Congresswoman Katherine Clark (D-Mass) and Congressman Ryan Costello […]

Continue Reading · 0

Postpartum Depression: Focus on Managing Comorbid Anxiety Symptoms

  Multiple studies have demonstrated the effectiveness of antidepressant medications for the treatment of postpartum depression (PPD).  Most of the these studies focused on the impact of these medications on depressive symptoms; however, it is clear that many, or maybe most, women with PPD also have significant anxiety symptoms.  Thus, we can hypothesize that medications […]

Continue Reading · 0
Credit: Depressed Mother from Wikimedia Commons

What Keeps Women with Perinatal Depression from Getting the Help They Need?

  The U.S. Preventive Services Task Force (USPSTF) recently released recommendations on Screening for Depression in Adults. The Task Force recommended that clinicians screen ALL ADULTS for depression and noted that screening in the primary care setting is beneficial. Echoing the recommendations made by the American College of Obstetricians and Gynecologists last year, the  USPSTF […]

Continue Reading · 0
Credit: Pregnant Woman from Wikimedia Commons

Predicting Postpartum Depression: Elevated Leptin Levels as Biomarker?

Biomarkers (or biological markers) are used in many fields of medicine to provide objective information on normal or pathological biological processes and to predict response to therapeutic interventions.  Researchers have long searched for biomarkers which could be used to identify women with postpartum depression (PPD) or, even better, to predict which women are at highest […]

Continue Reading · 0