postnatal depression

In Brief: ACOG Recommends Increased Level of Care During the “Fourth Trimester”

The American College of Obstetricians and Gynecologists (ACOG) has made a significant change to its recommendations for optimal postpartum care.  Previously, ACOG has recommended that women receive a single, comprehensive postpartum visit within the first [...]

Brexanolone: Related to Allopregnanolone, Effective for the Treatment of Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression.  SAGE-547, now called brexanolone, is an allosteric modulator of GABAA receptors.  This drug was initially under [...]

Depression and Hormonal Contraception: Should Depo-Provera Be Used in Postpartum Women?

Because estrogen-containing contraceptives may affect lactation and may increase the risk of thrombosis, progestin-only contraceptives are used in women who are breastfeeding.  Depo-Provera (DMPA), which contains medroxyprogesterone, is frequently used during the immediate postpartum period [...]