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Tag Archives | Paxil

Combining Tamoxifen with Antidepressants: What You Need to Know

Two thirds of all breast cancer tumors are known to have receptors that respond to hormones; that is they can grow in response to estrogen. Tamoxifen is a medication which selectively blocks estrogen receptors on breast cancer tumors and, in this fashion, reduces the risk of recurrence by half in women with estrogen receptor-positive breast […]

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SSRIs and Pregnancy: No Risk of Cardiovascular Malformations According to UK Study

Over the last few years, several studies have suggested an increased risk of certain types of cardiovascular malformations in children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports suggested a link between cardiac septal defects and exposure to paroxetine; other, but not all, studies have also shown an elevated risk of […]

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Antidepressants and Pregnancy: Are Some SSRIs Safer Than Others?

  Over the last decade, numerous studies on the reproductive safety of selective serotonin reuptake inhibitors (SSRIs) have been published.  However, these studies, using different methodologies and studying different populations, have often yielded conflicting results.  The extensive data now available in the medical literature can be difficult for clinicians and researchers to sort through. As […]

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Baby Belly from Wikimedia Commons

SSRIs and Pregnancy: No Increase in Risk of Malformations

Over the last few years, we have reported on several studies which have suggested an increased risk of certain types of cardiovascular malformations among children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports suggested a link between cardiac septal defects and exposure to paroxetine; other, but not all, studies have also shown an […]

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SSRI Antidepressants Not Associated with Cardiovascular Defects

Over the last few years, we have reported on several studies which have suggested an  increased risk of certain types of cardiovascular malformations among children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports suggested a link between cardiac septal defects and exposure to paroxetine; other, but not all, studies have also […]

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SSRI Antidepressants and Male Fertility

Back in 2009, we reported on a study which demonstrated that paroxetine (Paxil) may affect sperm quality in men treated with this antidepressant. A new study reports a similar finding in men treated with sertraline (Zoloft), another selective serotonin reuptake inhibitor (SSRI). In this randomized, single-blind study, men with premature ejaculation were treated with either […]

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SSRIs and Cardiovascular Malformations: Another Look

Over the last few years, we have reported on several studies which have suggested an increased risk of certain types of cardiovascular malformations among children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy.  The first reports suggested a link between cardiac septal defects and exposure to paroxetine; subsequent studies have also shown elevated risks with the other SSRIIs. 

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New Study Does Not Find Link Between Paroxetine and Cardiovascular Defects

In 2006, GlaxoSmithKline (GSK) elected to change product label warnings for the antidepressant paroxetine (Paxil), advising against the use of this drug by women who are pregnant. This decision was based on preliminary studies which suggested an increase in the risk of cardiovascular malformations among infants exposed to paroxetine in utero. A recent study from the Motherisk Program in Toronto has reported on the outcomes of over 3000 paroxetine-exposed infants.

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Can Paxil (Paroxetine) Be Used While Breastfeeding?

All medications are secreted into the breast milk, although concentrations appear to vary. There is a fair amount of information on the use of Paxil (paroxetine) in nursing women. While Paxil may be detected in the breast milk, there have been no reports of adverse events in the nursing infant. The only situation where one may want to avoid breastfeeding is when the baby is premature or has signs of hepatic immaturity, which may make it more difficult for the infant to metabolize the medication to which he or she is exposed. Premature babies are also probably more vulnerable to the toxic effects of these medications.

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