Mass General Hospital

Harvard Medical School

Tag Archives | major depression

Brexanolone: Related to Allopregnanolone, Effective for the Treatment of Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression.  SAGE-547, now called brexanolone, is an allosteric modulator of GABAA receptors.  This drug was initially under investigation for the treatment of refractory seizure disorders but it turned out to be a good antidepressant.  The information we […]

Continue Reading · 0

CBT for Depression During Pregnancy: Good for Moms, Good for Babies

Australian researchers have developed a cognitive behavioural therapy (CBT) treatment intervention for antenatal depression and anxiety.  Beating the Blues Before Birth, to be delivered as individual therapy, was adapted from a 12-session group intervention for postpartum depression previously developed by Milgrom and colleagues (Milgrom et al. 1999, 2005).  Interestingly, this intervention was modified for individual […]

Continue Reading · 0
Photo by Christoph Lehmann

Anxiety Symptoms and Risk for Perimenopausal Depression

A growing body of research indicates that the menopausal transition is a period of increased vulnerability to depressive illness.  Some women have experienced episodes of major depressive disorder (MDD) earlier in life and experience recurrent illness during the menopausal transition.  Other women, however, experience first lifetime-onset of MDD during this transition.  The identification of  specific […]

Continue Reading · 0
By Vera Kratochvil [Public domain], via Wikimedia Commons

Is It Postpartum Depression or Postpartum Anxiety? What’s The Difference?

Meet Christine.  She is a married 30-year-old woman who just had her first baby about 3 weeks ago.  While the pregnancy went smoothly, the experience of labor and delivery was difficult.  After nearly 20 hours of labor, Christine had an emergency caesarean section.  The baby was healthy, but he had difficulty breastfeeding.  Christine was worried […]

Continue Reading · 1

Measuring the Psychological Impact of Stillbirth and Neonatal Death

  Perinatal loss is a traumatic event for women and their families.  While we clearly understand the potential for perinatal loss to cause significant emotional consequences, we have little data on the prevalence of depressive illness and posttraumatic stress disorder in this population of women. A recent study contacted a total of 1400 women with […]

Continue Reading · 0
Credit: Depressed Mother from Wikimedia Commons

SAGE-547: A Novel Treatment for Severe Postpartum Depression?

SAGE-547 (SAGE Therapeutics) is a new drug, an allosteric modulator of GABAA receptors, which is currently under investigation for the treatment of refractory seizure disorders.  It turns out that SAGE-547 may also be useful for the treatment of severe postpartum depression (PPD). In a press release last month, SAGE Therapeutics announced data from an exploratory […]

Continue Reading · 1
Credit: Pregnant Woman from Wikimedia Commons

Brief Report: TMS for Depression During Pregnancy

Transcranial magnetic stimulation or TMS is similar to ECT but uses electromagnetic pulses to generate electrical current in specific regions of the brain that are known to modulate mood.  TMS is less likely to cause side effects and has thus been proposed as a possible alternative therapy for those suffering from treatment-resistant depression.  (You can […]

Continue Reading · 0

Women with Recurrent Pregnancy Loss at Risk for Depression and Anxiety

In a recent cross-sectional study from Denmark, researchers compared the prevalence of stress and depressive symptoms among 301 women with recurrent pregnancy loss (or RPL) and 1813 women attempting to conceive naturally. RPL was defined as three or more pregnancy losses before 12 weeks’ gestation. The Major Depression Index (MDI) was used to assess symptoms […]

Continue Reading · 0

Screening for Depression During Pregnancy May Lead to Misdiagnosis for Women with Bipolar Disorder

The American College of Obstetrics and Gynecology now recommends that women be screened for depression during pregnancy.  Because depressive symptoms during pregnancy have been associated with worse outcomes and are a robust predictor of postpartum depression, the identification of women with depression during pregnancy would help us to identify women in need of treatment and […]

Continue Reading · 1

ACOG Opinion: Depression Screening for All Pregnant and Postpartum Women

It is estimated that about 15% of women suffer from depression either during pregnancy or the postpartum period. Prior to the 1980s, most new mothers had never heard of postpartum depression.  Over the last few decades we have made considerable progress in educating women about their risk for psychiatric illness during this vulnerable time, and […]

Continue Reading · 3