major depression

Brexanolone: Related to Allopregnanolone, Effective for the Treatment of Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression.  SAGE-547, now called brexanolone, is an allosteric modulator of GABAA receptors.  This drug was initially under [...]

CBT for Depression During Pregnancy: Good for Moms, Good for Babies

Australian researchers have developed a cognitive behavioural therapy (CBT) treatment intervention for antenatal depression and anxiety.  Beating the Blues Before Birth, to be delivered as individual therapy, was adapted from a 12-session group intervention for [...]

Women with Recurrent Pregnancy Loss at Risk for Depression and Anxiety

In a recent cross-sectional study from Denmark, researchers compared the prevalence of stress and depressive symptoms among 301 women with recurrent pregnancy loss (or RPL) and 1813 women attempting to conceive naturally. RPL was defined [...]

Screening for Depression During Pregnancy May Lead to Misdiagnosis for Women with Bipolar Disorder

The American College of Obstetrics and Gynecology now recommends that women be screened for depression during pregnancy.  Because depressive symptoms during pregnancy have been associated with worse outcomes and are a robust predictor of postpartum [...]