birth defects

In Brief: Folate Supplements During Pregnancy Reduce Risk of Autism  

Mothers exposed to household or agricultural pesticides immediately before and during their pregnancies have a higher risk of having a child with autism spectrum disorder (ASD).  However, a recent study from California indicates that taking [...]

By |2017-11-08T22:20:23-04:00October 16th, 2017|Pregnancy & Medications|Comments Off on In Brief: Folate Supplements During Pregnancy Reduce Risk of Autism  

France Bans the Use of Valproic Acid in Some Women of Childbearing Age

There have long been concerns regarding the safety of the anticonvulsant valproate (Depakote) during pregnancy.  Back in 2009, the American Academy of Neurology and American Epilepsy Society recommended against the use of valproic acid in [...]

By |2017-08-11T08:57:58-04:00August 7th, 2017|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on France Bans the Use of Valproic Acid in Some Women of Childbearing Age

Lamotrigine and Pregnancy: Meta-Analysis Shows No Increase in Risk for Malformations

  Maintenance treatment with a mood stabilizer during pregnancy can significantly reduce the risk of relapse in women with bipolar disorder; however, many of the mood stabilizers commonly used in this setting, including lithium and [...]

By |2025-06-26T09:07:02-04:00May 8th, 2017|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Lamotrigine and Pregnancy: Meta-Analysis Shows No Increase in Risk for Malformations

New Research from the CWMH: Evaluating the Risk of Major Malformations in Children Prenatally Exposed to Atypical Antipsychotics

Despite the increasing use of the newer “atypical” or second-generation antipsychotic agents to treat a spectrum of psychiatric disorders, including schizophrenia, bipolar disorder, major depression, PTSD and other anxiety disorders, we have relatively little data [...]

By |2021-03-29T10:51:11-04:00June 3rd, 2016|Antipsychotic Medications, Outcomes, Pregnancy & Medications, Research at CWMH, Risk of Malformations|Comments Off on New Research from the CWMH: Evaluating the Risk of Major Malformations in Children Prenatally Exposed to Atypical Antipsychotics

Lamotrigine and Pregnancy: New Study, No Significant Increase in Risk of Oral Clefts

The anticonvulsant lamotrigine (Lamictal) is being used with increasing regularity for the treatment of women with bipolar disorder.  Back in 2006, we reported on preliminary data indicating an increased risk of oral clefts among infants [...]

By |2025-06-26T09:07:05-04:00April 11th, 2016|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Lamotrigine and Pregnancy: New Study, No Significant Increase in Risk of Oral Clefts

Antidepressants and Pregnancy: Are Some SSRIs Safer Than Others?

  Over the last decade, numerous studies on the reproductive safety of selective serotonin reuptake inhibitors (SSRIs) have been published.  However, these studies, using different methodologies and studying different populations, have often yielded conflicting results. [...]

By |2020-11-26T08:39:16-04:00July 10th, 2015|Antidepressants, Outcomes, Pregnancy & Medications|Comments Off on Antidepressants and Pregnancy: Are Some SSRIs Safer Than Others?

Topiramate and Pregnancy: More on Risk of Major Malformations

Topiramate (TPM, marketed as Topamax) is an antiepileptic drug which is also used for migraine prophylaxis, weight loss, and, less commonly, as a mood stabilizer.  Over the last few years we have seen several studies [...]

By |2015-07-07T15:19:19-04:00June 22nd, 2015|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Topiramate and Pregnancy: More on Risk of Major Malformations

You Asked: Gabapentin (Neurontin) and Pregnancy

While gabapentin (Neurontin) is now used in a wide variety of clinical settings — for epilepsy, pain management, restless leg syndrome, anxiety, and sleep disturbance – there is relatively little information regarding its reproductive safety.  [...]

By |2025-06-26T09:08:03-04:00May 13th, 2015|Anti-Anxiety Medications, Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on You Asked: Gabapentin (Neurontin) and Pregnancy

SSRIs and Pregnancy: No Increase in Risk of Malformations

Over the last few years, we have reported on several studies which have suggested an increased risk of certain types of cardiovascular malformations among children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports [...]

By |2015-07-08T11:24:15-04:00May 6th, 2015|Antidepressants, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on SSRIs and Pregnancy: No Increase in Risk of Malformations
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