birth defects

Accumulating Data on the Reproductive Safety of Second-Generation Antipsychotics, But Still Not Enough

In a cohort of 351 children exposed to second generation antipsychotic during pregnancy, the risk of major congenital malformations did not differ from a comparison group of non-exposed children.

By |2022-12-08T18:32:09-04:00June 21st, 2022|Antipsychotic Medications, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Accumulating Data on the Reproductive Safety of Second-Generation Antipsychotics, But Still Not Enough

Prospective Data on the Use of Newer Antipsychotics During Pregnancy: No Increase in Risk of Malformations

The most recent publication from the National Pregnancy Registry focuses on overall risk of malformations associated with the class of antipsychotic medications.

By |2021-09-09T15:55:20-04:00September 7th, 2021|Antipsychotic Medications, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Prospective Data on the Use of Newer Antipsychotics During Pregnancy: No Increase in Risk of Malformations

New Research from the CWMH: No Increase in Major Malformations in Children Prenatally Exposed to Aripiprazole

Despite the increasing use of the newer atypical or second-generation antipsychotic agents to treat a spectrum of psychiatric disorders, including psychotic disorders, bipolar disorder, major depression, PTSD and other anxiety disorders, we have relatively little [...]

By |2021-03-29T13:17:38-04:00March 30th, 2021|Antipsychotic Medications, Outcomes, Pregnancy & Medications, Research at CWMH, Risk of Malformations|Comments Off on New Research from the CWMH: No Increase in Major Malformations in Children Prenatally Exposed to Aripiprazole

Prescription Opioids During Pregnancy and Risk for Major Malformations

Previous studies have suggested a link between opioid exposure during pregnancy and increased risk of certain major malformations, including neural tube defects.  A recent study from Bateman and colleagues assesses the risk of major malformation [...]

By |2021-03-16T09:24:00-04:00March 16th, 2021|Opioids, Outcomes, Perinatal Substance Use, Pregnancy & Medications, Risk of Malformations|Comments Off on Prescription Opioids During Pregnancy and Risk for Major Malformations

Modafinil and Armodafinil During Pregnancy: Data to Suggest Increased Risk of Malformations

As soon as we published this article on the use of modafinil during pregnancy, another study was published which included data on the reproductive safety of modafinil and armodafinil from the US Provigil/Nuvigil Pregnancy [...]

By |2022-01-20T18:11:36-04:00November 4th, 2020|ADHD Medications, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Modafinil and Armodafinil During Pregnancy: Data to Suggest Increased Risk of Malformations

Assessing the Reproductive Safety of Antidepressants: Can Non-Randomized Studies Provide the Information We Need?

Perinatal psychiatry is a field in which we treat vulnerable patients, a mother and her child, where both the illness we are treating and the treatments we prescribe have the potential to affect the outcome.  [...]

By |2020-09-09T17:43:09-04:00September 3rd, 2020|Antidepressants, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Assessing the Reproductive Safety of Antidepressants: Can Non-Randomized Studies Provide the Information We Need?

Another Study on Antidepressants and Birth Defects: Does it Change Our Decision-Making?

Prozac (fluoxetine) was the first SSRI or selective serotonin reuptake inhibitor.  Since its release in 1988, we have been gathering data on the reproductive safety of fluoxetine and other SSRIs.  Over the last 32 years, [...]

By |2020-11-26T08:23:09-04:00August 25th, 2020|Antidepressants, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Another Study on Antidepressants and Birth Defects: Does it Change Our Decision-Making?

Clinical Update 2020: Lamotrigine (Lamictal) and Pregnancy

Clinical Update 2020:  Lamotrigine (Lamictal) and Pregnancy Maintenance treatment with a mood stabilizer during pregnancy can significantly reduce the risk of relapse in women with bipolar disorder; however, many of the mood stabilizers commonly [...]

By |2025-06-26T09:06:58-04:00July 28th, 2020|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Clinical Update 2020: Lamotrigine (Lamictal) and Pregnancy

You Asked: Should Women Taking Lamotrigine (Lamictal) Use Higher Dose of Folic Acid When Planning for Pregnancy?

We have really enjoyed our weekly virtual rounds.  It’s been a great opportunity to meet other perinatal psychiatrists in the community, and discussions with new people always brings up interesting clinical questions.  Last week [...]

By |2025-06-26T09:06:59-04:00May 20th, 2020|Anti-Epileptic Drugs, Pregnancy & Medications, Treatment, You Asked|Comments Off on You Asked: Should Women Taking Lamotrigine (Lamictal) Use Higher Dose of Folic Acid When Planning for Pregnancy?

Opioid Use in Pregnant and Postpartum Women: Resources and CDC Expert Commentary

According to a recent analysis of national data by the Centers for Disease Control, the number of pregnant women with opioid use disorder (as documented at the time of delivery) more than quadrupled from 1999 [...]

By |2019-02-26T11:35:56-04:00February 26th, 2019|Opioids, Perinatal Substance Use|Comments Off on Opioid Use in Pregnant and Postpartum Women: Resources and CDC Expert Commentary
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