Every week we review the most recent publications in women’s mental health, covering topics related to premenstrual symptoms, perinatal mood and anxiety disorders, use of medications in pregnant and breastfeeding women, perinatal substance use, and menopausal mental health.
For more detailed descriptions of many of these topics, you can sign up to receive our weekly CWMH NEWSLETTER which comes out every Thursday.
Ruta Nonacs, MD PhD
PMS AND PMDD |
No articles this week
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INFERTILITY AND MENTAL HEALTH |
No articles this week
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PSYCHIATRIC ILLNESS DURING PREGNANCY |
Racial Disparities in Diagnosis of Postpartum Mood and Anxiety Disorders Among Symptomatic Medicaid Enrollees, 2012-2015.
Only 19.8% of respondents with symptoms of a perinatal mood and anxiety disorder (PMAD) had a PMAD diagnosis between delivery and 3 months afterward. Black respondents were less likely to have PMAD diagnoses (adjusted odds ratio [AOR]=0.23, 95% CI=0.11-0.49) compared with White respondents. Among Black respondents, more comorbid conditions and more life stressors were statistically significantly associated with having a diagnosis (AOR=3.18, 95% CI=1.27-7.96 and AOR=3.12, 95% CI=1.10-8.88, respectively). These findings suggest that 1 in 5 women living in LMICs experience anxiety disorders during pregnancy and the postpartum period. Through small but impactful linguistic updates, the EPDS-US offers inclusive person-first language and eliminates confusing phrases or wording that may be perceived as judgmental. The goal of the adapted EPDS-US is to foster symptom disclosure in an environment of safety and trust. Pregnancy- and birth-related anxiety decreased significantly in the intervention group (IG) and 6 weeks after birth, the rate of women at risk for adverse mental outcome was significantly lower compared to the CG. Mindfulness scores improved significantly in the IG. The eMBI program did not show effectiveness with regard to general depressive or anxiety symptoms, however, positive results were demonstrated regarding pregnancy and birth-related anxiety and the prevention of postpartum depression.
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MEDICATIONS AND PREGNANCY |
Impact of genetic, sociodemographic, and clinical features on antidepressant treatment trajectories in the perinatal period.
continued antidepressant use during pregnancy is influenced by the severity of the disease rather than genetic predisposition as measured by polygenic risk scores (PGSs) for major depression (MDD), bipolar disorder (BD), and schizophrenia (SCZ).
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POSTPARTUM PSYCHIATRIC ILLNESS |
Perinatal sleep disruption and postpartum psychosis in bipolar disorder: Findings from the UK BDRN Pregnancy Study.
After controlling for prophylactic use of mood stabilising medication, the loss of at least one complete night of sleep across labour/delivery was associated with five times the odds of experiencing PP compared to no or less than one night of sleep loss across labour/delivery (OR 5.19, 95 % CI 1.45-18.54; p = 0.011). Weaning and depression: a closer look. review the relevant literature and conclude that post-weaning depression is a rare but severe complication of breastfeeding cessation. The prevalence of insomnia was 20.4%, and the prevalence of poor sleep quality was 67.8% across the first 6 months postpartum. Postpartum insomnia and poor sleep quality at the between-subject and within-subject levels tended to uniquely predict greater depressive and anxiety symptoms, even after controlling for demographic characteristics, prenatal insomnia, and prenatal poor sleep quality. Mothers of multiples experienced worse postpartum bonding, more stress, and more interrupted sleep than mothers of singletons.
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MEDICATIONS AND BREASTFEEDING |
No articles this week
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PERINATAL SUBSTANCE USE |
No articles this week
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MATERNAL MENTAL HEALTH AND CHILD OUTCOMES |
The impact of maternal depression, anxiety, and stress on early neurodevelopment in boys and girls.
Data from the Shanghai Birth Cohort Study: among 3379 mothers, 11.07 %, 5.42 %, and 34.85 % of women experienced depression, anxiety, and elevated stress, separately. As maternal prenatal scores increased, infant social-emotional scores decreased. Fetal exposure to maternal affective symptoms – specifically pregnancy-related anxiety – plays a substantial role in the development of infant self-regulation problems, potentially mediated by epigenetic modifications. Prenatal and postnatal maternal psychological distress is associated with brain white matter (WM) tract developmental alterations in a sex- and timing-dependent manner. Higher EPDS scores during the second trimester of pregnancy were associated with changes in WM microstructure in boys observed at 5 years of age. In contrast, higher EPDS scores at 3 months postpartum were associated with changes in WM microstructure in girls. |
MENOPAUSE AND MENTAL HEALTH |
Menopause-Associated Depression: Impact of Oxidative Stress and Neuroinflammation on the Central Nervous System-A Review. |
OTHER TOPICS IN WOMEN’S MENTAL HEALTH |
No articles this week
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