Over the last few years we have heard a great deal about neurosteroids, also known as neuroactive steroids. This class of compounds are steroid hormones produced in the brain and endocrine tissues which can [...]
Patients and clinicians may not be fully aware that women are at increased risk for depression during the menopausal transition. The U.S. Preventive Services Task Force (USPSTF) recommends that clinicians screen all adults for [...]
As women transition into the menopause, they experience a constellation of symptoms including vasomotor symptoms (hot flashes and night sweats), sleep disruption, problems with sexual functioning, and cognitive impairment. Women may also be more [...]
Perimenopausal vasomotor symptoms are triggered by a fall in circulating levels of estrogen and other sex steroids. It has been hypothesized that thermoregulatory centres in the hypothalamus play a crucial role in mediating the [...]
In 2008, the National Institutes of Health funded the Menopause Strategies: Finding Lasting Answers for Symptoms and Health or MSFlash clinical trials network. The primary goal of MSFlash has been to find and test new [...]
In our clinic, we often see women with symptoms of depression and anxiety which emerge in the context of the menopausal transition; many of these women have suffered for years with severe symptoms before [...]
While earlier observational studies suggested that hormone treatment may improve cognitive functioning in peri- and postmenopausal women, studies from the Women’s Health Initiative (WHI) demonstrated that estrogen replacement therapy started in postmenopausal women (65 [...]
About 80% of women experience vasomotor symptoms (VMS) – hot flashes and night sweats — as they transition into the menopause phase. For most, the symptoms are manageable, but for a sizeable subset of midlife [...]
Up to 80% of women experience symptoms as they transition into the menopause, including vasomotor symptoms, sleep disturbance, and depressive symptoms. While hormone replacement therapy and certain medications may be helpful, these interventions may have [...]
Increasing numbers of peri- and post-menopausal women request “bioidentical” rather than synthetic hormones. Although there is a tendency to think of bioidentical hormones as “all-natural”, they, like synthetic hormones, are manufactured in the laboratory. In [...]