Estrogen-containing menopausal hormone therapy (MHT) may lower blood levels of lamotrigine, potentially reducing its effectiveness in some women with bipolar disorder. What do we know about this interaction, and does the risk differ with oral, transdermal, or vaginal estrogen?
How should psychiatrists think about hormone therapy in perimenopause? This article explains when, why, and how to consider MHT for perimenopausal women with mood and anxiety symptoms.
As of October 2023, the Neurosteroid Intervention for Menopausal and Perimenopausal Depression is no longer recruiting participants. Over the last few years we have heard a great deal about neurosteroids, also known as neuroactive steroids. [...]
The transition to menopause, or perimenopause, represents the passage from reproductive to non-reproductive life. During the perimenopause, women experience irregular menstrual cycles, which reflect the large fluctuations in ovarian hormone [...]
Over the last few years we have heard a great deal about neurosteroids, also known as neuroactive steroids. This class of compounds are steroid hormones produced in the brain and endocrine tissues which can [...]
While earlier observational studies suggested that hormone treatment may improve cognitive functioning in peri- and postmenopausal women, studies from the Women’s Health Initiative (WHI) demonstrated that estrogen replacement therapy started in postmenopausal women (65 [...]
About 80% of women experience vasomotor symptoms (VMS) – hot flashes and night sweats — as they transition into the menopause phase. For most, the symptoms are manageable, but for a sizeable subset of midlife [...]
Increasing numbers of peri- and post-menopausal women request “bioidentical” rather than synthetic hormones. Although there is a tendency to think of bioidentical hormones as “all-natural”, they, like synthetic hormones, are manufactured in the laboratory. In [...]
Early observational studies suggested that hormone replacement therapy (HRT) may improve cognitive functioning in postmenopausal women; however, larger studies, including the Women’s Health Initiative, have shown that estrogen replacement therapy started in postmenopausal women (65 [...]
Multiple studies have demonstrated that the menopausal transition is associated with a 2- to 4-fold increased risk for clinically significant depressive symptoms. There have been several studies suggesting that hormone therapy may improve depressive [...]
