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Tag Archives | estrogen

In Brief: Hormone Replacement Has No Impact on Mortality in Women

While there have been concerns regarding the risks associated with prolonged use of hormone replacement, an increasing number of studies suggest that the risk may be relatively low in certain populations and that hormone replacement is appropriate in certain settings.  A recent study published in JAMA has focused on mortality rates in women treated with […]

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Hormonal Contraception Linked to a (Small) Increase in Risk for Depression

We commonly receive questions regarding the potential effects of oral contraceptives (birth control pills) on mood and risk for depression.  Despite the prevalence of OC usage, few studies have explored the association between hormonal contraceptive use and mood disturbance.  According to a large Danish study of more than one million young women, the use of […]

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Premenstrual Mood Disorders and Postpartum Depression: Similar But Different

It has been hypothesized that both premenstrual dysphoric disorder (PMDD) and postpartum depression (PPD) occur as the result of rapid shifts in the levels of ovarian hormones. Data regarding the prevalence of PPD among women with documented PPD is sparse, and the existent studies rely upon recall of premenstrual symptoms which is notoriously inaccurate.  Despite […]

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Photo by Christoph Lehmann https://www.flickr.com/photos/grooovy_easy/5255389744/in/photolist-91pfh1-5oVsER-pFpnRy-ec2MCd-gF9N97-5b3Vne-4NFhyn-8iQxd7-dUwWK-99SzT7-oEz9b9-6Bd2RD-64wPBn-bRpiQ6-6pQf1X-6CCqez-a7FBLH-9hhcsM-hhqhvC-Hx3Lu-w8y2T4-qpERyX-5FKSzJ-8MiyXg-2hvEdW-RBDAe-qxxAD4-4PRiP1-nE2Gaf-iGVY57-4VahiX-9DGHg9-r2EXfL-3hshNC-gGgjkR-buckND-jBwuQM-tQZcDc-qUzYP5-82899z-tyamDh-Hx9Ur-ciRYs5-jjzkxT-fp455D-2JrfTi-hy318h-5mZDc7-q61Z2D-dywyCa

Earlier Age at Menopause Increases Risk of Depression

Estrogens have neuroprotective and antidepressant effects.  During the perimenopause, when estrogen levels fluctuate and then fall significantly, women are more vulnerable to depression and cognitive deficits.  A recent study has investigated the association between age at menopause and risk for depression in postmenopausal women with naturally occurring menopause. In this meta-analysis, data was obtained from […]

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Photo by Christoph Lehmann https://www.flickr.com/photos/grooovy_easy/5255389744/in/photolist-91pfh1-5oVsER-pFpnRy-ec2MCd-gF9N97-5b3Vne-4NFhyn-8iQxd7-dUwWK-99SzT7-oEz9b9-6Bd2RD-64wPBn-bRpiQ6-6pQf1X-6CCqez-a7FBLH-9hhcsM-hhqhvC-Hx3Lu-w8y2T4-qpERyX-5FKSzJ-8MiyXg-2hvEdW-RBDAe-qxxAD4-4PRiP1-nE2Gaf-iGVY57-4VahiX-9DGHg9-r2EXfL-3hshNC-gGgjkR-buckND-jBwuQM-tQZcDc-qUzYP5-82899z-tyamDh-Hx9Ur-ciRYs5-jjzkxT-fp455D-2JrfTi-hy318h-5mZDc7-q61Z2D-dywyCa

NAMS Urges Prescribers to Avoid Bioidentical Hormones

According to data presented at the annual meeting of the North American Menopause Society (NAMS)  in Las Vega, a growing number of perimenopausal women are asking their doctors for compounded or bioidentical hormones.  Although bioidentical hormones are touted as being “natural”, they, like synthetic hormones, are manufactured in the laboratory.   Bioidentical hormones are chemically identical […]

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In Brief:  Improving Cognition in Schizophrenia by Modulating the Estrogen Receptor

This article in Psychiatric Times reviews some interesting research which suggests that drugs which modulate the estrogen receptor may improve cognitive functioning in patients with schizophrenia.  This is the first study to show that oral adjunctive treatment with raloxifene (120 mg per day) has beneficial effects on attention/processing speed and memory for both men and […]

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In Brief: Venlafaxine as Effective as Low-Dose Estradiol for Menopausal Sleep Symptoms

Which treatment is best for managing menopausal sleep problems? We tend to think of estrogen replacement therapy as being the best option for all menopausal symptoms; however, there are other options for managing menopausal symptoms, including serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors, and gabapentin. A recent study compares low-dose estradiol and low-dose venlafaxine for the […]

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Photo by Christoph Lehmann https://www.flickr.com/photos/grooovy_easy/5255389744/in/photolist-91pfh1-5oVsER-pFpnRy-ec2MCd-gF9N97-5b3Vne-4NFhyn-8iQxd7-dUwWK-99SzT7-oEz9b9-6Bd2RD-64wPBn-bRpiQ6-6pQf1X-6CCqez-a7FBLH-9hhcsM-hhqhvC-Hx3Lu-w8y2T4-qpERyX-5FKSzJ-8MiyXg-2hvEdW-RBDAe-qxxAD4-4PRiP1-nE2Gaf-iGVY57-4VahiX-9DGHg9-r2EXfL-3hshNC-gGgjkR-buckND-jBwuQM-tQZcDc-qUzYP5-82899z-tyamDh-Hx9Ur-ciRYs5-jjzkxT-fp455D-2JrfTi-hy318h-5mZDc7-q61Z2D-dywyCa

Proving the Estrogen Withdrawal Hypothesis of Perimenopausal Depression

Because women appear to be at increased risk for new onset and recurrent depression as they transition into the menopause, it has been hypothesized that declining ovarian function — or estrogen “withdrawal” — may trigger depressive symptoms in some women.  While this is a very reasonable and totally plausible hypothesis, no studies have formally tested […]

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In Brief: Some Menopausal Symptoms Worse in Women with Depression

Nearly a third of postmenopausal women experience vaginal changes, including dryness, itching and pain during sex — symptoms related to the declining levels of estrogen occurring during the transition to menopause.  According to a study which included 745 postmenopausal women with vaginal symptoms, it appears that these symptoms may be more disruptive for women who […]

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Photo by Christoph Lehmann https://www.flickr.com/photos/grooovy_easy/5255389744/in/photolist-91pfh1-5oVsER-pFpnRy-ec2MCd-gF9N97-5b3Vne-4NFhyn-8iQxd7-dUwWK-99SzT7-oEz9b9-6Bd2RD-64wPBn-bRpiQ6-6pQf1X-6CCqez-a7FBLH-9hhcsM-hhqhvC-Hx3Lu-w8y2T4-qpERyX-5FKSzJ-8MiyXg-2hvEdW-RBDAe-qxxAD4-4PRiP1-nE2Gaf-iGVY57-4VahiX-9DGHg9-r2EXfL-3hshNC-gGgjkR-buckND-jBwuQM-tQZcDc-qUzYP5-82899z-tyamDh-Hx9Ur-ciRYs5-jjzkxT-fp455D-2JrfTi-hy318h-5mZDc7-q61Z2D-dywyCa

New Research from the CWMH: Both Estradiol and Venlafaxine Improve Quality of Life in Perimenopausal Women with Hot Flashes

In healthy perimenopausal women with hot flashes, treatment with both estradiol and venlafaxine resulted in significantly greater improvement in quality of life, as compared to placebo. Estradiol had beneficial treatment effects on all domains of the MENQOL except for the psychosocial domain, whereas venlafaxine benefits were observed only in the psychosocial domain.   Caan B, LaCroix […]

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