epilepsy

Antiepileptic Drugs in Breastfeeding: Neurodevelopmental Outcomes

Because breastfeeding has many psychological and medical benefits for both the mother and her child, many women would like to breastfeed.  However, all medications taken by the mother are secreted into the breast milk.  While various studies have addressed the safety of antiepileptic drugs (AEDs) in nursing infants, none have systematically assessed the long-term effects of exposure to these drugs on the cognitive development of children exposed to these agents through breastfeeding.  This is an especially important issue as it has been demonstrated that certain AEDs, most notably valproic acid, may negatively affect the developing brain, a process which occurs in utero and into the first few decades of the child’s life.

By |2025-06-26T09:08:17-04:00January 24th, 2011|Anti-Epileptic Drugs, Breastfeeding & Medications, Child Outcomes, Neurodevelopmental Disorders, Outcomes|Comments Off on Antiepileptic Drugs in Breastfeeding: Neurodevelopmental Outcomes

Fetal Exposure to Valproate Associated with Lower IQ

There have long been concerns regarding the use of the anticonvulsant valproate (Depakote) during pregnancy.  First trimester use of valproate has been associated with a 3-5% risk of neural tube defects, as well as an increased risk of other malformations affecting the heart, limbs, and genitals. A recent report published in the New England Journal of Medicine indicates that in utero exposure to valproate may also result in lower IQ.     

By |2025-06-26T09:08:20-04:00April 24th, 2009|Anti-Epileptic Drugs, Bipolar Disorder, Long-Term Outcomes, Mood Stabilizers, Neurodevelopmental Disorders, Outcomes, Pregnancy & Medications|Comments Off on Fetal Exposure to Valproate Associated with Lower IQ
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