depression - MGH Center for Women's Mental Health

Pregnancy May Lower Lamotrigine (Lamictal) Blood Levels

Women with bipolar disorder are at increased risk for recurrence of illness during pregnancy. Therefore, many women with bipolar disorder elect to continue treatment with medications during pregnancy after weighing the risks and benefits of various treatment options with their physicians. Lamotrigine (Lamictal) is an anticonvulsant used to treat bipolar disorder. While the safety data on this relatively new anticonvulsant in pregnancy is limited, pregnancy registry data suggests that lamotrigine may pose less of a risk to the developing fetus than with older anticonvulsants, such as valproate (Depakote). With lamotrigine emerging as an effective and relatively safe treatment for pregnant women with bipolar disorder, more attention is now being paid to the effects of pregnancy on lamotrigine levels.

By MGH Center for Women's Mental Health|2018-07-11T13:30:12-04:00May 5th, 2009|Psychiatric Disorders During Pregnancy|1 Comment

A Mouse Model of Postpartum Depression

Maguire and Mody's report, GABAA R Plasticity during Pregnancy: Relevance to Postpartum Depression, in the July 2008, Neuron, provides evidence that an abnormal Gamma-aminobutyric acid (GABAA) receptor subunit in pregnant mice may be a useful model for postpartum depression. The report describes how GABAA receptors, specifically, the delta-subunit-containing GABA receptor, are a preferred target for neurosteroids. They designed a study to identify functional changes in these receptors during pregnancy and postpartum and then looked at possible behavioral correlates in the mice.

By MGH Center for Women's Mental Health|2015-08-12T14:07:14-04:00March 10th, 2009|Postpartum Psychiatric Disorders|0 Comments

Mood and well-being after removal of both ovaries

The risk of depression after removal of both ovaries (also called bilateral oöphorectomy or surgical menopause) is a major factor for women to consider when they confront medical problems that require removal of the uterus (called a hysterectomy). Many women are advised to consider having their ovaries removed when they are having the uterus removed. Sometimes removal of the ovaries is required to fully treat the condition leading to surgery, but other times it is suggested as a precaution to reduce the risk of ovarian cancer. Removal of both ovaries in a premenopausal woman results in an abrupt withdrawal of estrogen, progesterone, and testosterone. Therefore removing both ovaries (rather than just one or neither ovary) may have significant effects on mood and well-being in women.

By MGH Center for Women's Mental Health|2015-08-12T14:02:54-04:00February 24th, 2009|Menopausal Symptoms|13 Comments

SSRIs in Pregnancy and Neonatal Distress Syndrome

Most obstetricians are now familiar with the potential for what has become known as neonatal distress syndrome (or "adaptation" syndrome) following third trimester exposure to SSRIs. Some patients still worry about the possibility of their baby developing neonatal distress syndrome, especially if anything unusual happened during the post-delivery experience of an earlier pregnancy. Women may be concerned about whether and to what degree the medication they were on played a role in their infant's distress and whether to continue that medication during a subsequent pregnancy. The following case may help illustrate the decision-making dilemmas.

By MGH Center for Women's Mental Health|2015-08-12T14:01:29-04:00February 17th, 2009|Psychiatric Disorders During Pregnancy|1 Comment

Maternal depression, in-home violence, and use of physical punishment

Parental use of physical punishment early in childhood may be associated with subsequent maladaptive behaviors such as child aggression and impaired social information processing. There are links between certain childhood behaviors and risk for parental use of physical punishment, although cause and effect are difficult to establish with these associations. Higher rates of physical punishment correlate with maternal depression and domestic violence.

By MGH Center for Women's Mental Health|2015-08-12T12:27:53-04:00January 26th, 2009|Postpartum Psychiatric Disorders|0 Comments

Cognitive Behavioral Therapy Used to Treat Depression in Pregnancy

Mood disorders and symptoms during pregnancy and the postpartum period are not uncommon and affect women across the world. In spite of relatively high rates of depression among childbearing women, there are often inadequate resources for treatment, particularly in poorer countries. In countries lacking resources, health care is often managed by community health workers or individuals with basic health care training who provide care to difficult-to-reach populations. There are often few mental health professionals, leaving many women without adequate treatment. In an attempt to provide treatment to a greater number of women, some investigators are attempting to train community health workers to provide some psychotherapy as part of their standard duties.

By MGH Center for Women's Mental Health|2016-03-14T12:20:53-04:00January 13th, 2009|Postpartum Psychiatric Disorders, Psychiatric Disorders During Pregnancy|0 Comments

Sildenafil (Viagra) Treatment of Women with Antidepressant-Associated Sexual Dysfunction

While some side effects such as nausea, dizziness, and headaches associated with selective serotonin reuptake inhibitor (SSRI) antidepressants tend to decrease or resolve over time, other side effects such as sexual dysfunction rarely remit spontaneously. Treatment of sexual side effects in women is especially important when about 30-70% of patients taking antidepressants may experience sexual side effects, combined with the fact that women are prescribed antidepressants at rates of 2 to 1 when compared to men.

By MGH Center for Women's Mental Health|2015-08-12T12:23:22-04:00January 6th, 2009|Women's Mental Health|0 Comments

Bipolar Disorder and PMS

Premenstrual worsening of mood is common among women with depression, but little is known about how often women with bipolar disorder experience worsening of their mood premenstrually. In a study by Payne et al. (2007), premenstrual symptoms were reported by twice as many women diagnosed with mood disorders (mixture of Bipolar Disorder and Major Depressive Disorder) than by women who did not have a psychiatric diagnosis (67.7% vs. 33.7%). These results suggest that PMS symptoms are particularly common in women with bipolar disorder and major depressive disorder. However, this study involved women reporting prior experiences with PMS, which is not always as accurate as studies that involve prospective monitoring to obtain real-time reporting of PMS symptoms. Such prospective studies of PMS in women with bipolar disorder are sparse and have inconsistent conclusions.

By MGH Center for Women's Mental Health|2016-03-28T13:38:38-04:00December 15th, 2008|New Research, PMS and PMDD|12 Comments

Exercise and Depression

Exercise plays a vital role in achieving and maintaining good health. Along with numerous other health benefits, recent studies have shown that exercise alleviates symptoms of depression and may be useful in treating mild to moderate major depressive disorder (MDD). A study by Dunn and colleagues (2005) examined the efficacy of exercise as a treatment for depression, along with the dose-response relationship of exercise and reduction in depressive symptoms.

By MGH Center for Women's Mental Health|2015-08-12T12:05:36-04:00November 24th, 2008|Postpartum Psychiatric Disorders, Psychiatric Disorders During Pregnancy|2 Comments

Depression during Pregnancy Increases the Risk of Preterm Delivery

A new study reported in Human Reproduction supports what many other studies have found, that untreated depression during pregnancy increases the likelihood of delivering before 37 weeks gestation.

By MGH Center for Women's Mental Health|2015-08-12T11:47:05-04:00November 3rd, 2008|Psychiatric Disorders During Pregnancy|0 Comments