• congenital malformations

    Anti-Epileptic Drugs in Reproductive eAge Women: Valproic Acid and Topiramate Commonly Used

    There have long been concerns regarding the safety of the anticonvulsant valproic acid (Depakote) during pregnancy.  Back in 2009, the American Academy of Neurology and American Epilepsy Society recommended against the use of valproic acid [...]

    FDA Announces Approval of a New (Old) Medication for Nausea and Vomiting in Pregnancy

    The combination of doxylamine succinate and pyridoxine hydrochloride (vitamin B6), to be marketed as Diclegis, has been approved by the FDA for the treatment of nausea and vomiting in pregnancy. A similar combination was previously sold under the name Bendectin but was pulled from the market in 1983 because there were concerns regarding its reproductive safety.  (Bendectin originally contained dicyclomine which was later removed due to lack of efficacy.)

    Duloxetine and Pregnancy: Preliminary Data

    Duloxetine (sold in the United Sates under the brand name of Cymbalta) is a serotonin-norepinephrine reuptake inhibitor (SNRI) effective for major depressive disorder and generalized anxiety disorder (GAD).  Although used fairly commonly in women of child-bearing age, information regarding its reproductive safety has been lacking.

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