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Tag Archives | congenital malformation

Higher Doses of Topiramate (Topamax) During Pregnancy, Increased Risk of Oral Clefts

Topiramate (TPM, marketed as Topamax) is an antiepileptic drug which is also used for migraine prophylaxis, weight loss, and, less commonly, as a mood stabilizer.  Over the last few years we have seen several studies suggesting an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy.  A large […]

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Good News: More Data on the Use of ADHD Medications During Pregnancy

For women with mild to moderate attention-deficit/hyperactivity disorder (ADHD) symptoms, we often recommend discontinuing stimulant medications and switching to a non-pharmacologic intervention.  Many women experience some decrease in their level of functioning; however, they are able to forgo or minimize pharmacologic treatment during pregnancy.  There are, however, women who experience more severe symptoms which interfere […]

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More Data on Pregabalin (Lyrica) and Pregnancy

Pregabalin (marketed in the US as Lyrica) is approved by the US Food and Drug Administration for the treatment of epilepsy, fibromyalgia, and neuropathic pain.  It is also used off-label to treat psychiatric disorders, most commonly generalized anxiety disorder.  While it is not used as frequently as other anti-epileptic drugs, we do occasionally see women […]

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USPSTF Emphasizes Periconceptual Use of Folic Acid to Prevent Birth Defects

Neural tube defects are among the most common major congenital anomalies in the United States and are associated with significant disability and death.  The risk of neural tube defects can be prevented with daily folic acid supplementation in the periconceptional period.  However, most women do not receive the recommended daily intake of folate.  January 5–11 […]

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Baby Belly from Wikimedia Commons

New Research from the CWMH: Prenatal Exposure to Atypical Antipsychotics Does Not Increase Risk of Malformations

The use of the newer “atypical” or second-generation antipsychotic agents continues to increase.  These medications are used to treat a spectrum of psychiatric disorders, including schizophrenia, bipolar disorder, major depression, PTSD and anxiety disorders.  Although most of the women taking atypical antipsychotics are of childbearing age, our information on the reproductive safety of these newer […]

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By Ragesoss - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=4544244

You Asked: What Dose of Folic Acid for Pregnant Women Taking Lamotrigine (Lamictal)?

In our community of perinatal psychiatrists, we have recently seen many questions regarding the use of folic acid supplementation in women taking lamotrigine (Lamictal).  While all recognize that all women of childbearing age should receive folic acid supplementation, there is considerable variation regarding the dose that should be recommended for women taking lamotrigine (Lamictal). Folic […]

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Pregabalin (Lyrica) and Pregnancy: Preliminary Data

Pregabalin (marketed in the US as Lyrica) is approved by the US Food and Drug Administration for the treatment of epilepsy, fibromyalgia, and neuropathic pain.  It is also used off-label to treat psychiatric disorders, most commonly generalized anxiety disorder.  While it is not used as frequently as other anti-epileptic drugs, we do occasionally see women […]

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Baby Belly from Wikimedia Commons

SSRIs and Pregnancy: No Risk of Cardiovascular Malformations According to UK Study

Over the last few years, several studies have suggested an increased risk of certain types of cardiovascular malformations in children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports suggested a link between cardiac septal defects and exposure to paroxetine; other, but not all, studies have also shown an elevated risk of […]

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Topiramate and Pregnancy: More on Risk of Major Malformations

Topiramate (TPM, marketed as Topamax) is an antiepileptic drug which is also used for migraine prophylaxis, weight loss, and, less commonly, as a mood stabilizer.  Over the last few years we have seen several studies suggesting an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy.  A recent […]

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Baby Belly from Wikimedia Commons

SSRIs and Pregnancy: No Increase in Risk of Malformations

Over the last few years, we have reported on several studies which have suggested an increased risk of certain types of cardiovascular malformations among children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports suggested a link between cardiac septal defects and exposure to paroxetine; other, but not all, studies have also shown an […]

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