antidepressants - MGH Center for Women's Mental Health

Antidepressants and Risk of Spontaneous Abortion

Although the last several decades of research have yielded important findings regarding the safety of antidepressants during pregnancy, some areas are still understudied. For example, there are no conclusive results concerning the risk of spontaneous abortions following antidepressant exposure during the first trimester. Several recent meta-analyses, including one from the Motherisk program (Hemels, 2005), have observed an increased risk of spontaneous abortion among women taking antidepressants.

By MGH Center for Women's Mental Health|2015-08-12T16:45:03-04:00June 21st, 2010|Psychiatric Disorders During Pregnancy|1 Comment

When Health Care Providers Say the Wrong Thing

With increasing frequency, postpartum women who have taken antidepressants during pregnancy have shared – usually in tears – that while in the hospital for their labor and delivery hospitalization, a health care provider at the hospital said something judgmental about their being on an antidepressant. For example, one woman said that a nurse told her, “I can’t believe you took that during pregnancy.” Or, “Don’t you know how risky that is?!” Or “How could you do that to your baby?” This is often in the context of women using other medications in parallel for non-psychiatric indications, of which less may be known about the reproductive safety profile, but not addressed by the health care provider.

By MGH Center for Women's Mental Health|2015-08-12T16:30:09-04:00April 14th, 2010|Psychiatric Disorders During Pregnancy|7 Comments

Premenstrual Syndromes: What is the Optimal Duration of Treatment?

Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD) affect a large number of women of childbearing age. 30-80% of reproductive age women experience premenstrual symptoms. PMS refers to a pattern of physical, emotional, and behavioral symptoms occurring 1-2 weeks before menses and remitting with the onset of menses. Common symptoms include fatigue, poor concentration, mild mood changes, headaches, abdominal bloating, and breast tenderness.

By MGH Center for Women's Mental Health|2015-08-12T15:32:28-04:00December 21st, 2009|PMS and PMDD|2 Comments

Paroxetine (Paxil) May Affect Sperm Quality

Within the field of psychiatry, there is a growing body of literature studying the use of antidepressants in women in the context of pregnancy and the postpartum period. However, much less attention has focused on the impact of these drugs on fertility, particularly in men. Because major depressive disorders affect about one in 10 American men over their lifetimes, it is essential to study the effects of antidepressants on male fertility.

By MGH Center for Women's Mental Health|2015-07-28T13:31:57-04:00October 1st, 2009|Infertility and Mental Health|4 Comments

Generic Medications

Many patients ask questions about generic medications, wondering how they differ and if they’re as safe and as effective as the more expensive brand name versions. To better understand this concept, we’ll discuss an example.

By MGH Center for Women's Mental Health|2015-08-12T14:56:26-04:00August 10th, 2009|Women's Mental Health|0 Comments

Mental Health Parity in Massachusetts

Recent changes expanded the scope of mental health parity in the Commonwealth of Massachusetts, which requires insurance companies to cover specified diagnoses on a “nondiscriminatory basis”. This means that copayments, deductibles, coinsurance, unit of service limits- such as hospital days and outpatient visits, and/or annual or lifetime maximums are no greater for mental disorders when compared to physical conditions.

By MGH Center for Women's Mental Health|2015-08-12T14:51:49-04:00July 16th, 2009|Psychiatric Disorders During Pregnancy|1 Comment

Antenatal Use of SSRIs and QT Interval Prolongation in Newborns

Over the last several years, a number of studies have indicated that exposure to antidepressants near the time of delivery may be associated with poor neonatal outcomes. A recent prospective study from Dubnov-Raz and colleagues published in the journal Pediatrics found an association between QTc interval prolongation in neonates and antenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants. The QT interval is a measurement of the heart's electrical cycle from ventricular depolarization to the end of ventricular polarization. It is determined from an electrocardiogram (ECG) and is corrected for heart rate.

By MGH Center for Women's Mental Health|2015-08-12T14:14:31-04:00March 24th, 2009|Psychiatric Disorders During Pregnancy|0 Comments

Using New Research to Inform Treatment Decisions during Pregnancy: A Case Report

As more research is conducted within the field of women's mental health, there are times when recommendations may change depending on the available data. We will discuss a case here to illustrate this point.

By MGH Center for Women's Mental Health|2015-08-12T14:09:25-04:00March 17th, 2009|Psychiatric Disorders During Pregnancy|2 Comments

Grapefruit Juice May Affect Drug Absorption

CYP3A4 is an intestinal enzyme that is part of the Cytochrome P450 metabolic system. It is important in many drug-drug and drug-food interactions, and it is one of the first enzymes to break down medications when they enter the body.

By MGH Center for Women's Mental Health|2015-08-12T12:31:07-04:00February 2nd, 2009|Women's Mental Health|0 Comments

Stress During Pregnancy Increases ADHD Risk

While genetic factors are clearly important in determining a child’s risk for attention deficit hyperactivity disorder (ADHD), recent studies have investigated the link between exposure to certain maternal behaviors during pregnancy, such as smoking and alcohol use, and the risk of developing behavioral problems related to attention deficit hyperactivity disorder in childhood. While multiple studies have indicated a greater risk of ADHD symptoms among children whose mothers smoked during pregnancy, contradictory findings were reported in studies focusing on exposure to alcohol. Results from studies investigating the impact of psychological stress during pregnancy have been inconsistent but suggest a possible contribution to ADHD symptoms int he offspring.

By MGH Center for Women's Mental Health|2015-07-28T10:07:59-04:00May 10th, 2008|Psychiatric Disorders During Pregnancy|0 Comments