Neurodevelopmental Outcomes in Children with Prenatal Exposure to Antiepileptic Drugs: A Systematic Review
A systematic review examines neurodevelopmental outcomes in children prenatally exposed to antiepileptic drugs.
Still Not Enough Data on the Reproductive Safety of Oxcarbazepine (Trileptal)
This meta-analysis is reassuring regarding risk for malformations in children exposed prenatally to oxcarbazepine; however, we still need more data to fully assess reproductive safety.
Prenatal Exposure to Topiramate (Topamax):Â Impact on Neurodevelopmental Outcomes
Data from a Nordic register-based study observed a significant increase in risk for autism spectrum disorder and intellectual disability in children with prenatal exposure to topiramate.
Essential Reads: Prenatal Valproate Exposure and Risk of Autism in Children
Prenatal exposure to valproic acid was associated with an increased risk of autism spectrum disorder in exposed children.
Reassuring News: Neurodevelopmental Outcomes in Two-Year Olds with Prenatal Exposure to Lamotrigine (Lamictal)
These findings are encouraging and suggest that the newer AEDs, specifically lamotrigine and levetiracetam, are not associated with worse neurodevelopmental outcomes.
Essential Reads: Neurodevelopmental Outcomes in Children with Prenatal Exposure to Antiepileptic Drugs
There is a growing body of literature to indicate that exposure to certain antiepileptic drugs, most notably valproic acid (VPA, Depakote) during critical periods of development may be associated with long-lasting neurodevelopmental deficits.
Prenatal Exposure to Valproic Acid Linked to Increased Risk for Autism, ADHD
Prenatal exposure to valproate has been associated with an elevated risk (10%) for a broad range of congenital malformations including neural tube defects, as well as adverse neurodevelopmental sequelae, including lower IQ and developmental delays [...]
Lithium and Anticonvulsant Mood Stabilizers: No Higher Risk for Adverse Pregnancy Outcomes
For women with bipolar disorder, choosing whether to maintain or discontinue treatment with a mood stabilizer during pregnancy is challenging. This is a process which requires careful and thoughtful consideration, weighing the risk of adverse [...]
Behavior Problems More Common In Children with Prenatal Exposure to Valproic Acid
While we have considerable information regarding the teratogenic risk associated with prenatal exposure to various antiepileptic (AED) drugs, we have less impact on exposure to AEDs on behavior outcomes in children. Several studies have shown [...]
Anti-Epileptic Drugs in Reproductive Age Women: Valproic Acid and Topiramate Commonly Used
There have long been concerns regarding the safety of the anticonvulsant valproic acid (Depakote) during pregnancy. Â Back in 2009, the American Academy of Neurology and American Epilepsy Society recommended against the use of valproic acid [...]