• Menopausal Symptoms

    More on Vitamin D and Depression

    We have recently written about the link between vitamin D and depression.  While several studies have indicated that low vitamin D levels may be associated with depression, we lack randomized, controlled trials assessing the benefits of vitamin D supplements for the treatment (or prevention) of depression.  A recent report from the Women's Health Initiative Calcium and Vitamin D Trial included 36,282 women (50 to 80 years of age) who were randomized to receive 400 IU vitamin D (with 1000 mg calcium) or to placebo. 

    By |2020-07-27T12:45:01-04:00September 5th, 2012|Menopausal Symptoms|0 Comments

    New Research from the CWMH: Escitalopram and Sleep in Midlife Women with Vasomotor Symptoms

    Selective serotonin and serotonin-norepinephrine inhibitors (SSRIs and SNRIs) have been shown to be effective for the treatment of hot flashes.  However, these agents may carry certain side effects, including sexual side effects and sleep disturbance.  These two side effects may be particularly concerning to peri- and postmenopausal women who, in addition to having vasomotor symptoms, are more likely to experience sexual dysfunction and sleep disruption than premenopausal women.

    Weight Loss and a Low-Fat Diet Help to Reduce Hot Flashes in Menopausal Women

    Various studies have shown that women with a higher body mass index (BMI) or a higher percent of body fat have more frequent or more severe menopausal symptoms.  In a recent study, researchers evaluated the impact of a low-fat diet on vasomotor symptoms in a group of 17,473 postmenopausal women between the ages of 50 and 79.

    New Research from the CWMH: Surgically Induced Menopause No Worse than Natural in Terms of Risk for Depression, Anxiety

    Each year about 600,000 women in the United States undergo a hysterectomy.  Somewhere between 55% and 80% of these women who also have their ovaries removed along with the uterus—a procedure known as oophorectomy.  After the removal of the ovaries, menopause follows immediately and is associated with a constellation of symptoms including hot flashes and insomnia, as well as depression and anxiety. 

    New Research from the CWMH: History of Depression and Anxiety Predict Lower Quality of Life in Midlife Women

    The National Comorbidity Survey estimates that by the time women reach midlife, approximately 23% have experienced at least one episode of major depression and 30% have been diagnosed with an anxiety disorder.  Depression and anxiety disorders are each associated with impaired functioning and lower quality of life (QOL).  There is also some data to suggest that, even after a depressive episode resolves, those with a history of a affective illness have a lower quality of life than those without histories of depression, with impairment in social and interpersonal functioning.

    Soy Supplements: No Effect on Cognition in Postmenopausal Women

    Soy-based products have long been touted as a treatment for menopausal symptoms.  However, many of the clinical studies measuring the effectiveness of dietary sources of soy isoflavones (e.g., soy beverages, soy powder) for the treatment of menopausal vasomotor symptoms (i.e., hot flushes, night sweats) have been negative.  Less is known about the effects of soy on cognition.  A large clinical trial suggests that soy may not have any positive effects on cognition in postmenopausal women.

    In Brief: Menopausal Symptoms Usually Go Untreated

    In this study, half of women aged 45 to 60 years reported experiencing menopausal symptoms. 69% of these women reported that their symptoms have negatively  affected their lives. Among the women who endorsed menopausal symptoms, 72% had not received any treatment for their symptoms and 77% reported that they had not discussed treatment options with their healthcare providers.

    A New Website to Help Educate Menopausal Women about Their Treatment Options

    Ever since 2002 when several large-scale studies called into question the safety of long-term hormone replacement therapy (HRT), there has been confusion and conflicting opinions regarding the management of menopausal symptoms. Initially there was a movement to avoid HRT altogether; now it is becoming clearer that certain women may safely use and benefit from hormonal interventions.

    New Research from the CWMH: Progestins Do Not Negatively Affect Mood in Peri- and Postmenopausal Women

    More than half of all women initiating treatment with hormone therapy will stop within the first year of treatment, most often because of side effects.  Mood disturbance is a relatively common side effect that occurs with hormone therapy, and previous studies have suggested that progestins in the combined hormone preparations are responsible for these negative mood effects.

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