• Essential Reads

    Essential Reads: Bupropion (Wellbutrin) and Risk for Major Malformations

    Bupropion is commonly used to treat depression, and is also prescribed to support smoking cessation. Early data on bupropion-exposure during pregnancy raised concern for a possible increase in risk of malformations of the heart and large blood vessels in bupropion-exposed infants. Subsequent data from bupropion pregnancy registries has been reassuring, however, and do not demonstrate an overall increase in risk of cardiac defects following first trimester bupropion exposure. Although the overall risk of cardiac defects was not increased, the distribution of specific defects in these registries was unexpected in some ways. For example, the GlaxoSmithKline Bupropion Pregnancy Registry included two cases of coarctation of the aorta out of the 675 bupropion-exposed infants, compared to the rate of 6 cases per 10,000 births in the general population.

    Essential Reads: Should Lithium Dose Be Reduced Prior to Delivery?

    The dosing of lithium presents certain challenges during pregnancy.  During pregnancy, there is a physiologic increase in the glomerular filtration rate (GFR), which is a measure of how quickly the kidney clears renally excreted compounds, [...]

    Essential Reads: Evidence-Based Interventions for Depressed Mothers and Their Young Children

    In a given year, about 10% of mothers in the United States experience a major depressive episode (MDE).  Roughly translated, this means about 1 in 10 children is exposed to maternal depression each year (Ertel [...]

    Go to Top