• Yearly Archives: 2013

    Do SSRIs Increase the Risk of Postpartum Hemorrhage? Maybe, But Not By Much

    Selective serotonin reuptake inhibitor (SSRI) antidepressants may affect platelet aggregation and thus may increase the risk of bleeding.  Several studies have sought to determine if exposure to SSRI antidepressants in late pregnancy is associated with an increased risk of postpartum hemorrhage.

    Earlier Age of Surgical Menopause Associated with More Significant Cognitive Decline

    Previous studies have shown that the abrupt hormonal changes that occur after a surgical menopause (i.e., removal of the ovaries) negatively affect cognition in women.  According to a recent study, "Women who were younger at the time of surgical menopause have a more rapid rate (steeper slope) of cognitive decline than women who were older at the time of surgery or than women undergoing natural menopause."  Earlier age at menopause was also associated with increased Alzheimer’s disease neuropathology, in particular neuritic plaques.

    By |2016-07-21T11:33:53-04:00December 23rd, 2013|Menopausal Symptoms|0 Comments

    Novel Approaches to Antidepressant-Induced Sexual Side Effects: Exercise and Acupuncture

    Sexual side effects may occur in 40% to 70% of patients treated with serotonin reuptake inhibitors (SRIs) and is a common reason for poor compliance with treatment and eventual discontinuation. When sexual side effects occur, they tend to emerge early, are persistent, and rarely resolve spontaneously.  A new study, reviewed in Medscape, suggests that exercise may help to reduce sexual side effects:

    Understanding the Link between Trauma History and Risk of Perinatal Depression

    While we are becoming more attentive to screening for depressive symptoms during pregnancy and the postpartum period, we may not always ask about a history of trauma, especially when a woman has had what most would consider an “uncomplicated” pregnancy. A recent study, however, indicates that a history of trauma may be a risk factor for depression during pregnancy.

    Levetiracetam (Keppra) and Pregnancy

    While it is well-established that several of the older anticonvulsants, including valproate (Depakote), carry a significant teratogenic risk, less is known about the reproductive safety of the newer antiepileptic drugs (AEDs).  A new report from the U.K. and Ireland Epilepsy and Pregnancy Registers suggests that the risk of malformations associated with levetiracetam (LVT, Keppra) use during pregnancy is low.

    Interpersonal Therapy Based Intervention Reduces the Risk of Postpartum Depression in Teen Mothers

    Postpartum depression (PPD) is a relatively common problem, affecting between 10% and 15% of women after delivery. Although it is difficult to reliably predict which women in the general population will experience postpartum mood disturbance, it is possible to identify certain subgroups of women who are more vulnerable.   One such group is teen mothers, where the risk of PPD is about 25%.

    Antenatal Exposure to Depression or Anxiety Increases the Risk of Adolescent Depression

    Many studies have demonstrated an increased risk for depression among the children of mothers with depression.  Exactly how this vulnerability to depression is transmitted to the child is not precisely understood.  Genetic factors clearly play an important role, but there are other important factors which contribute to the intergenerational transmission of depression.  For example, many studies have shown that postpartum depression may contribute to parenting styles which increase a child’s likelihood of developing depression later on.   While the child appears to be particularly sensitive to the effects of maternal depression during the first year of life, it appears that older children are also affected by maternal depression and are more likely to suffer from depression and other psychiatric symptoms than children with non-depressed mothers.

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