Mass General Hospital

Harvard Medical School



SSRI Antidepressants Not Associated with Cardiovascular Defects

Over the last few years, we have reported on several studies which have suggested an  increased risk of certain types of cardiovascular malformations among children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports suggested a link between cardiac septal defects and exposure to paroxetine; other, but not all, studies have also […]

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New Research from the CWMH: CBT to Reduce Risk of Relapse in Women Attempting to Discontinue Antidepressants

Pregnancy is a time of risk for women with histories of major depression. In a study where 201 women with histories of recurrent depression were followed prospectively through pregnancy, 43% experienced a relapse of major depression during pregnancy. Relapse rates were highest in the group of women who elected to discontinue antidepressant treatment proximate to […]

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Breastfeeding and Anti-Epileptic Medications

Because breastfeeding has many psychological and medical benefits for both the mother and her child, many women would like to breastfeed. However, all medications taken by the mother are secreted into the breast milk. While various studies have addressed the short-term safety of antiepileptic drugs (AEDs) in nursing infants, none have systematically assessed the long-term […]

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In the New York Times: Understanding Maternal Mental Illness

This week in the New York Times, there is a two-part story on maternal mental illness. Highlighting the experience of two women who became ill during the postpartum period, the articles focus on the range of disorders which can emerge during the postpartum period — not only depression, but bipolar disorder, anxiety, OCD, and psychosis.

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Antidepressants and Weight Gain: Which Ones are the Worst Offenders?

Many women are understandably concerned about the risk of weight gain associated with antidepressants. It is difficult to advise them as to which antidepressants are less or more likely to cause weight gain, as there are no head-to-head comparisons. In a recent electronic health record study including data from 22,610 individuals, 19,244 of which were […]

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