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Tag Archives | antidepressant

Credit: Pregnant Woman from Wikimedia Commons

The 50-year Quest for Better Pregnancy Data

The following post was first published in OB/GYN News. Please see our OB/GYN News archives here. Publish date: November 1, 2016 By: Gerald G. Briggs, BPharm, FCCP, Christina Chambers, PhD, MPH, Lee S. Cohen, MD, & Gideon Koren, MD Editor’s note: As Ob.Gyn. News celebrates its 50th anniversary, we wanted to know how far the medical community has come in identifying and […]

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Combining Tamoxifen with Antidepressants: What You Need to Know

Two thirds of all breast cancer tumors are known to have receptors that respond to hormones; that is they can grow in response to estrogen. Tamoxifen is a medication which selectively blocks estrogen receptors on breast cancer tumors and, in this fashion, reduces the risk of recurrence by half in women with estrogen receptor-positive breast […]

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By Vera Kratochvil [Public domain], via Wikimedia Commons

More Data on SAGE-547, A Novel Treatment for Severe Postpartum Depression

About a year ago, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression.  SAGE-547  is a new drug, an allosteric modulator of GABAA receptors, which was initially under investigation for the treatment of refractory seizure disorders.  It turns out that SAGE-547 may also be useful for the […]

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SSRIs and Pregnancy: No Risk of Cardiovascular Malformations According to UK Study

Over the last few years, several studies have suggested an increased risk of certain types of cardiovascular malformations in children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports suggested a link between cardiac septal defects and exposure to paroxetine; other, but not all, studies have also shown an elevated risk of […]

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Credit: Pregnant Woman from Wikimedia Commons

Taking A Closer Look: Autism and Antidepressants

Earlier this week, JAMA Pediatrics released the findings of a study which suggested that prenatal exposure to antidepressants may increase the risk of autism spectrum disorders (ASDs). Not surprisingly, this has created a considerable amount of anxiety among women taking these medications.  While the headlines may prompt women and their treaters to avoid these medications, […]

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Credit: Pregnant Woman from Wikimedia Commons

Venlafaxine and Duloxetine: Pooled Analysis Shows No Increase in Risk of Malformations

Women face difficult choices when deciding whether or not to continue psychiatric medications during pregnancy.  This choice can be especially difficult for women taking newer medications which lack adequate reproductive safety data.  While we have adequate data regarding the reproductive safety of most of the selective serotonin reuptake inhibitors (SSRIs), there has been less information […]

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Photo by Christoph Lehmann https://www.flickr.com/photos/grooovy_easy/5255389744/in/photolist-91pfh1-5oVsER-pFpnRy-ec2MCd-gF9N97-5b3Vne-4NFhyn-8iQxd7-dUwWK-99SzT7-oEz9b9-6Bd2RD-64wPBn-bRpiQ6-6pQf1X-6CCqez-a7FBLH-9hhcsM-hhqhvC-Hx3Lu-w8y2T4-qpERyX-5FKSzJ-8MiyXg-2hvEdW-RBDAe-qxxAD4-4PRiP1-nE2Gaf-iGVY57-4VahiX-9DGHg9-r2EXfL-3hshNC-gGgjkR-buckND-jBwuQM-tQZcDc-qUzYP5-82899z-tyamDh-Hx9Ur-ciRYs5-jjzkxT-fp455D-2JrfTi-hy318h-5mZDc7-q61Z2D-dywyCa

Research Study: Vortioxetine for Perimenopausal and Postmenopausal Women

The menopausal transition is a difficult time for many women.  There is an increased risk of depressive episodes during this transition in the reproductive lifecycle, and the majority of women will experience symptoms related to perimenopause (such as hot flashes, sleep disturbance, and cognitive complaints). Vortioxetine (brand name Brintellix) is a novel antidepressant that was […]

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SSRI Antidepressants and PPHN: Much Lower Risk Than Previously Reported

In 2006, Chambers and colleagues published an article linking selective serotonin reuptake inhibitor (SSRI) antidepressant use during late pregnancy to an increased risk of persistent pulmonary hypertension in the newborn (PPHN). PPHN is a cardiovascular syndrome typically occurring in full-term or near-term infants. After birth, the infant’s pulmonary vascular resistance remains high; blood is shunted […]

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You Asked: Is Duloxetine (Cymbalta) Safe To Use During Pregnancy?

You can find a more recent post on this topic here: Venlafaxine and Duloxetine: Pooled Analysis Shows No Increase in Risk of Malformations We receive a fair number of questions on the use of duloxetine during pregnancy.  Duloxetine (sold in the United Sates under the brand name of Cymbalta) is a serotonin-norepinephrine reuptake inhibitor (SNRI) […]

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Treating Depression During Pregnancy Prevents Postpartum Depression

This is a relatively small study but I think it underscores the importance of screening for and treating depression during pregnancy.  Previous studies have indicated that about 10% to 15% of women experience clinically significant depressive symptoms during pregnancy; however, depression that emerges during pregnancy often goes untreated. A recent naturalistic study from Turkey followed […]

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