This review article provides clinically relevant data but also helps the reader navigate some of the more controversial issues in the field.   Â
SSRI and SNRI antidepressants were not associated with an increased risk for gestational diabetes.
In this large study with over 1500 exposures, duloxetine exposure during the first trimester does not appear to increase risk of major malformations.
The current study indicates that duloxetine administered at a dose of 60 mg does not have an impact on sperm quality.
A recent study from Rommel and colleagues looks at risk for affective illness up to 18 years of age in children with prenatal exposure to antidepressants.
The reality is that most of the antidepressants taken by women today are relatively safe and carry a very low risk to the developing fetus.Â
Bupropion is commonly used to treat depression, and is also prescribed to support smoking cessation. Early data on bupropion-exposure during pregnancy raised concern for a possible increase in risk of malformations of the heart and large blood vessels in bupropion-exposed infants. Subsequent data from bupropion pregnancy registries has been reassuring, however, and do not demonstrate an overall increase in risk of cardiac defects following first trimester bupropion exposure. Although the overall risk of cardiac defects was not increased, the distribution of specific defects in these registries was unexpected in some ways. For example, the GlaxoSmithKline Bupropion Pregnancy Registry included two cases of coarctation of the aorta out of the 675 bupropion-exposed infants, compared to the rate of 6 cases per 10,000 births in the general population.
While we have data to support the use of antidepressants, including the selective serotonin reuptake inhibitors (SSRIs) and the serotonin norepinephrine reuptake inhibitors (SNRIs), during pregnancy, most studies have focused on risk of congenital [...]
Many women ask whether taking antidepressants may increase the risk for miscarriage or spontaneous abortion. Some, but not all, studies have demonstrated an increased risk of miscarriage among women who use antidepressants. However, it has [...]
This is the first installment of a new feature on our website: ESSENTIAL READS This is a kind of shortcut which allows you to find the most relevant reviews and articles in reproductive psychiatry. [...]
