EURAP is an international registry for antiepileptic drugs and pregnancy. At its inception in 1999, it included only European countries but EURAP has grown and now includes 42 countries from Europe, Australia, Asia, South America. [...]
There have long been concerns regarding the use of the anticonvulsant valproate (Depakote) during pregnancy. First trimester use of valproate has been associated with a 3-5% risk of neural tube defects, as well as [...]
There have long been concerns regarding the safety of the anticonvulsant valproate (Depakote) during pregnancy. Back in 2009, the American Academy of Neurology and American Epilepsy Society recommended against the use of valproic acid in [...]
There have long been concerns regarding the use of the anticonvulsant valproate (Depakote) during pregnancy. First trimester use of valproate has been associated with a 3-5% risk of neural tube defects, as well as [...]
The CDC, the U.S. Public Health Service, and the American College of Obstetricians and Gynecologists (ACOG) all recommend that every woman of reproductive age get 400 micrograms (400 mcg) or 0.4 milligrams of folic acid [...]
Many of the newer antiepileptic drugs (AEDs) have uses beyond the treatment of epilepsy. Topiramate (marketed as a Topamax), in addition to its use for the treatment of epilepsy, is now being prescribed to reproductive [...]
Several studies have observed that fetal exposure to the antiepileptic drug (AED), valproic acid (Depakote), may significantly increase the risk of having a child with an autism spectrum disorder. In contrast, exposures to other AEDs, [...]
There have long been concerns regarding the use of the anticonvulsant valproate (Depakote) during pregnancy. First trimester use of valproate has been associated with a 3-5% risk of neural tube defects, as well as [...]
The European Medicine Agency (EMA)'s Pharmacovigilance and Risk Assessment Committee recently recommended strengthening the restrictions on the use of valproic acid in women of reproductive age. Over the last few years, we have seen a host of articles documenting the deleterious effects of valproic acid on the developing fetus:
We have an abundance of articles which address the impact of psychotropic medications on pregnancy. Much less research, however, has focused on how pregnancy may affect how these medications work. Physiologic changes take place during [...]
