valproic acid

Lithium and Anticonvulsant Mood Stabilizers: No Higher Risk for Adverse Pregnancy Outcomes

For women with bipolar disorder, choosing whether to maintain or discontinue treatment with a mood stabilizer during pregnancy is challenging.  This is a process which requires careful and thoughtful consideration, weighing the risk of adverse [...]

By |2025-06-26T09:07:40-04:00August 5th, 2019|Pregnancy & Medications|Comments Off on Lithium and Anticonvulsant Mood Stabilizers: No Higher Risk for Adverse Pregnancy Outcomes

Behavior Problems More Common In Children with Prenatal Exposure to Valproic Acid

While we have considerable information regarding the teratogenic risk associated with prenatal exposure to various antiepileptic (AED) drugs, we have less impact on exposure to AEDs on behavior outcomes in children.  Several studies have shown [...]

By |2025-06-26T09:07:41-04:00July 15th, 2019|Anti-Epileptic Drugs, Neurodevelopmental Disorders, Outcomes, Pregnancy & Medications|Comments Off on Behavior Problems More Common In Children with Prenatal Exposure to Valproic Acid

Anti-Epileptic Drugs in Reproductive Age Women: Valproic Acid and Topiramate Commonly Used

There have long been concerns regarding the safety of the anticonvulsant valproic acid (Depakote) during pregnancy.  Back in 2009, the American Academy of Neurology and American Epilepsy Society recommended against the use of valproic acid [...]

By |2025-06-26T09:07:43-04:00April 9th, 2019|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Anti-Epileptic Drugs in Reproductive Age Women: Valproic Acid and Topiramate Commonly Used

Valproic Acid: Highlighting Risk and Modifying Prescribing Patterns in Reproductive Age Women

For clinicians who have not yet discovered the incredibly thoughtful and clinically practical monthly articles from Chittaranjan Andrade in the Journal of Clinical Psychiatry, it’s time to take a look.  (Not only are these articles [...]

By |2019-04-05T08:04:27-04:00July 3rd, 2018|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Valproic Acid: Highlighting Risk and Modifying Prescribing Patterns in Reproductive Age Women

Antiepileptic Drugs and Pregnancy: The Good,The Bad, and The Ugly

EURAP is an international registry for antiepileptic drugs and pregnancy.  At its inception in 1999, it included only European countries but EURAP has grown and now includes 42 countries from Europe, Australia, Asia, South America. [...]

By |2025-06-26T09:07:47-04:00May 1st, 2018|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Antiepileptic Drugs and Pregnancy: The Good,The Bad, and The Ugly

Prenatal Valproic Acid Exposure and Poor School Performance in Older Children

  There have long been concerns regarding the use of the anticonvulsant valproate (Depakote) during pregnancy.  First trimester use of valproate has been associated with a 3-5% risk of neural tube defects, as well as [...]

By |2025-06-26T09:07:50-04:00April 17th, 2018|Pregnancy & Medications|Comments Off on Prenatal Valproic Acid Exposure and Poor School Performance in Older Children

France Bans the Use of Valproic Acid in Some Women of Childbearing Age

There have long been concerns regarding the safety of the anticonvulsant valproate (Depakote) during pregnancy.  Back in 2009, the American Academy of Neurology and American Epilepsy Society recommended against the use of valproic acid in [...]

By |2017-08-11T08:57:58-04:00August 7th, 2017|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on France Bans the Use of Valproic Acid in Some Women of Childbearing Age

Why Are We Still Using Valproic Acid (Depakote) in Women of Childbearing Age?

  There have long been concerns regarding the use of the anticonvulsant valproate (Depakote) during pregnancy.  First trimester use of valproate has been associated with a 3-5% risk of neural tube defects, as well as [...]

By |2020-11-26T08:28:56-04:00May 22nd, 2017|Anti-Epileptic Drugs, Pregnancy & Medications, Risk of Malformations|Comments Off on Why Are We Still Using Valproic Acid (Depakote) in Women of Childbearing Age?

Prenatal Antiepileptic Exposure Increases Risk for Malformations: Does High-Dose Folic Acid Reduce Risk?

The CDC, the U.S. Public Health Service, and the American College of Obstetricians and Gynecologists (ACOG) all recommend that every woman of reproductive age get 400 micrograms (400 mcg) or 0.4 milligrams of folic acid [...]

By |2016-10-24T09:32:36-04:00October 24th, 2016|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Prenatal Antiepileptic Exposure Increases Risk for Malformations: Does High-Dose Folic Acid Reduce Risk?

Prenatal Exposure to Levetiracetam and Topiramate: No Evidence of Cognitive Deficits

Many of the newer antiepileptic drugs (AEDs) have uses beyond the treatment of epilepsy.  Topiramate (marketed as a Topamax), in addition to its use for the treatment of epilepsy, is now being prescribed to reproductive [...]

By |2016-10-03T11:24:32-04:00October 3rd, 2016|Pregnancy & Medications|Comments Off on Prenatal Exposure to Levetiracetam and Topiramate: No Evidence of Cognitive Deficits
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