Essential Reads: Oxcarbazepine (Trileptal) and Pregnancy
Given limited data on the reproductive safety of oxcarbazepine, we would recommend using alternate medications during pregnancy, when possible.
Clinical Update (2019): Is Oxcarbazepine (Trileptal) Safe to Use During Pregnancy?
We don’t hear this clinical question so often but it does come up from time to time. While the anticonvulsant oxcarbazepine (Trileptal) was initially promoted as a mood stabilizer for patients with bipolar disorder, it [...]
Oxcarbazepine (Trileptal) and Pregnancy: Do We Have Enough Information?
Last week in clinical rounds we discussed a case of a woman with bipolar disorder who was planning a pregnancy. She had a long history of illness, experiencing primarily depressive episodes since her early [...]
From the North American AED Pregnancy Registry: The Newer Anticonvulsants Appear to Be Safer
While it is well-established that several of the older anticonvulsants, including valproate (Depakote), carry a significant teratogenic risk, less is known about the reproductive safety of the newer antiepileptic drugs (AEDs). The North American AED Pregnancy Registry was established in 1997 for pregnant women in the United States and Canada at the Massachusetts General Hospital. The purpose of the registry is to obtain and publish information on the frequency of major malformations among infants whose mothers have taken one or more AEDs during pregnancy.