Is It Safe to Use Hydroxyzine During Pregnancy?
Hydroxyzine is used frequently for the management of anxiety and sleep problems during pregnancy. However, there is limited information regarding its reproductive safety.
Essential Reads: Prenatal Exposure to Valproate and Risk of Neurodevelopmental Disorders in Offspring
Prenatal exposure to valproate is linked to increased risk of autism spectrum disorder, ADHD, lower IQ, and intellectual disability, especially at higher doses.
Essential Reads: Why Non-Randomized Studies Fall Short When Assessing Reproductive Safety
All of our information on the reproductive safety of medications comes from non-randomized studies. However, many of these studies fail to take into consideration other factors associated with maternal psychiatric illness which may also affect outcomes.
New Research from the CWMH: Preliminary Data on the Reproductive Safety of Buspirone (BuSpar)
Although a small sample, no major malformations were observed in a prospectively followed cohort of women with first trimester exposure to buspirone.
Essential Reads: Duloxetine and Pregnancy (2021)
In this large study with over 1500 exposures, duloxetine exposure during the first trimester does not appear to increase risk of major malformations.
Essential Reads: Lithium and Pregnancy
While the use of lithium has been in decline over the last 20 years, lithium continues to be a useful and highly effective mood stabilizer for women with bipolar disorder, especially those with a history [...]
Assessing the Reproductive Safety of Antidepressants: Can Non-Randomized Studies Provide the Information We Need?
Perinatal psychiatry is a field in which we treat vulnerable patients, a mother and her child, where both the illness we are treating and the treatments we prescribe have the potential to affect the outcome. [...]
Clinical Update 2020: New Data on Duloxetine and Pregnancy
A few weeks ago, we published a clinical update for duloxetine (Cymbalta) and pregnancy, stating that there was little new to report since we last covered the topic in 2015. It is somewhat amusing [...]
Clinical Update 2020: Duloxetine and Pregnancy
Women face difficult choices when deciding whether or not to continue psychiatric medications during pregnancy. For many years, we have typically recommended the older antidepressants, including the selective serotonin reuptake inhibitors or SSRIs such [...]