Mass General Hospital

Harvard Medical School

Tag Archives | SSRI

Why Do Many Continue To Recommend Tapering SSRI Antidepressants During the Third Trimester?

  In 2005, we saw the first reports describing an increased risk of “poor neonatal adaptation” in infants with prenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants in late pregnancy.  Since that time, studies have consistently indicate that about 25%-30% of infants exposed to SSRIs late in pregnancy manifest symptoms of poor neonatal adaptation. […]

Continue Reading · 0

No Association Between Intellectual Disability and Prenatal Antidepressant Exposure

We have long been interested in understanding the effects of prenatal exposure to antidepressants on the development of the fetal brain.  The earliest studies addressing this question were small but yielded detailed (and reassuring) information regarding the cognitive development of children exposed to antidepressants in utero.  The findings of these studies supported the hypothesis that […]

Continue Reading · 0

Minimal Effects of Prenatal SSRIs on Motor Development in Exposed Children

When we meet with women to discuss the reproductive safety of antidepressant medications, one of the most challenging and anxiety-provoking aspects of the consultation is the discussion we have regarding the long-term effects of prenatal antidepressant exposure on the child.  Because studies assessing the effects of prenatal exposure to medication (or other environmental exposures) take […]

Continue Reading · 0

Risk of Neonatal Morbidity in Infants Exposed to SSRIs

A few days ago, an article was published in the journal Pediatrics on neonatal morbidity observed in children exposed to antidepressants.  Although this article is likely to find its way into the headlines, it is important to note that the information presented here is nothing new.  Similar to previous studies, the Pediatrics study reveals higher […]

Continue Reading · 0

Prenatal SSRI Exposure and Speech/Language Disorders: Many Headlines, Little Risk

Last week, an article looking at the cognitive and motor development of children with prenatal exposure to antidepressants was published in JAMA Psychiatry.  Since that time, we have received a lot of questions regarding the article and the clinical implications of its findings.  When I did a quick Google search, I found 36 articles reviewing […]

Continue Reading · 0
Credit: Pregnant Woman from Wikimedia Commons

Antidepressants and Postpartum Hemorrhage: No Risk with SSRIs, Small Risk with SNRIs

Serotonin reuptake inhibitor (SRI) antidepressants may affect platelet aggregation and thus may increase the risk of bleeding.  Several studies have sought to determine if exposure to SSRI antidepressants in late pregnancy is associated with an increased risk of postpartum hemorrhage. The most recent study was a population-based cohort study including 225,973 women with a total […]

Continue Reading · 0
Baby Belly from Wikimedia Commons

SSRIs and Pregnancy: No Risk of Cardiovascular Malformations According to UK Study

Over the last few years, several studies have suggested an increased risk of certain types of cardiovascular malformations in children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports suggested a link between cardiac septal defects and exposure to paroxetine; other, but not all, studies have also shown an elevated risk of […]

Continue Reading · 0

Postpartum Hemorrhage in Women Taking Antidepressants During Pregnancy

Serotonin reuptake inhibitor (SRI) antidepressants may affect platelet aggregation and thus may increase the risk of bleeding.  Several studies have sought to determine if exposure to SSRI antidepressants in late pregnancy is associated with an increased risk of postpartum hemorrhage. The most recent study comes from Australia and analyzes risk for postpartum hemorrhage in a […]

Continue Reading · 0
Credit: Pregnant Woman from Wikimedia Commons

Taking A Closer Look: Autism and Antidepressants

Earlier this week, JAMA Pediatrics released the findings of a study which suggested that prenatal exposure to antidepressants may increase the risk of autism spectrum disorders (ASDs). Not surprisingly, this has created a considerable amount of anxiety among women taking these medications.  While the headlines may prompt women and their treaters to avoid these medications, […]

Continue Reading · 1
Credit: Depressed Mother from Wikimedia Commons

Antidepressant Effects on Motor Development Minimal, According to New Study

When we meet with women to discuss the reproductive safety of antidepressant medications, one of the most challenging and anxiety-provoking aspects of the consultation is the discussion we have regarding the long-term effects of prenatal antidepressant exposure on the child.  Does antidepressant exposure during the earliest stages of brain development have lasting effects? Because studies […]

Continue Reading · 0