SAGE Therapeutics

More Data on the Neuroactive Steroid Zuranolone for Postpartum Depression

While we have heard a lot about brexanolone, marketed by Sage Therapeutics as Zulresso, for the treatment of postpartum depression, an oral version of this novel antidepressant – SAGE 217 or zuranolone – has been [...]

By |2026-03-10T12:50:13-04:00September 14th, 2020|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off on More Data on the Neuroactive Steroid Zuranolone for Postpartum Depression

Development of Zuranolone (SAGE 217) for PPD Will Move Forward

Zuranolone or SAGE-217 is similar to brexanolone (marketed as Zulresso), the medication which was FDA-approved for the treatment of  postpartum depression. Zuranolone is a neurosteroid, an analogue of allopregnanolone, which is a positive allosteric [...]

By |2026-03-10T12:50:14-04:00April 9th, 2020|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off on Development of Zuranolone (SAGE 217) for PPD Will Move Forward

Don’t Forget About Brexanolone’s Little Sister: Zuranolone

While we have been talking about using brexanolone, marketed by Sage Therapeutics as Zulresso, for the treatment of postpartum depression, an oral version of this novel antidepressant - SAGE 217 or zuranolone - has [...]

By |2026-03-10T12:50:16-04:00January 7th, 2020|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off on Don’t Forget About Brexanolone’s Little Sister: Zuranolone

Moving Forward with Brexanolone (Zulresso): Pilot Program at the Cleveland Clinic

It has been a few months since Zulresso (brexanolone), the new FDA-approved treatment for postpartum depression, has been available.  At our clinic, we have had multiple queries regarding how to obtain treatment with Zulresso. One [...]

By |2019-09-11T22:08:22-04:00September 10th, 2019|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off on Moving Forward with Brexanolone (Zulresso): Pilot Program at the Cleveland Clinic

Brexanolone (Zulresso) for Postpartum Depression Cleared by the DEA, Now Available

Brexanolone, to be marketed by Sage Therapeutics as Zulresso, was initially approved in March 2019, as a treatment for postpartum depression.  At that time, we were told that Zulresso would be available in June 2019. [...]

By |2020-01-05T14:34:41-04:00July 11th, 2019|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off on Brexanolone (Zulresso) for Postpartum Depression Cleared by the DEA, Now Available

FDA is Expected to Approve Brexanolone for the Treatment of Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD).  SAGE-547, now called brexanolone, is an allosteric modulator of GABAA receptors.  Since that time, Sage Therapeutics [...]

By |2019-03-18T22:49:26-04:00March 18th, 2019|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off on FDA is Expected to Approve Brexanolone for the Treatment of Postpartum Depression

Oral Allopregnanolone Analogue for Postpartum Depression Treatment

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD).  SAGE-547, now called brexanolone, is a neurosteroid, an analogue of allopregnanolone and an allosteric modulator of [...]

By |2019-01-13T15:57:09-04:00January 14th, 2019|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off on Oral Allopregnanolone Analogue for Postpartum Depression Treatment

FDA Supports Intravenous Brexanolone for Postpartum Depression

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD).  SAGE-547, now called brexanolone, is an allosteric modulator of GABAA receptors.  Since that time, Sage Therapeutics [...]

By |2018-11-10T10:02:56-04:00November 10th, 2018|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off on FDA Supports Intravenous Brexanolone for Postpartum Depression

Brexanolone for Postpartum Depression: More Data, But Still Some Questions

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of severe postpartum depression (PPD).  SAGE-547, now called brexanolone, is an allosteric modulator of GABA-A receptors.  We saw the preliminary [...]

By |2018-11-08T11:05:46-04:00September 26th, 2018|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off on Brexanolone for Postpartum Depression: More Data, But Still Some Questions
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