New Research from the CWMH: Data on the Reproductive Safety of Vortioxetine
New prospective data on 56 first-trimester vortioxetine exposures found no major malformations, offering reassuring but still preliminary reproductive safety information.
New Research from the CWMH: Data on the Reproductive Safety of Cariprazine
New registry data found no major malformations among 58 infants exposed to cariprazine in the first trimester, offering reassuring but preliminary reproductive safety evidence.
You Asked: What is Lithium Orotate? Can It Be Used During Pregnancy?
Lithium orotate is a lithium salt marketed as a supplement, but we do not have evidence that it is an effective or safer mood stabilizer, and it should not be used as a substitute for standard lithium treatment in pregnancy.
Topiramate and Risk of Major Malformations: What Clinicians and Patients Need to Know
Topiramate exposure in early pregnancy is linked to higher rates of major malformations and more specifically to increased risk of oral clefts, with risk rising at higher doses.
Clinical Update 2026: Z-Drugs and Pregnancy
Recent studies find no increase in the risk of major malformations with first-trimester Z-drug exposure, although small increases in risk of preterm birth and low birth weight have been reported.
Essential Reads: Mirtazapine (Remeron) and Pregnancy
While we have adequate data to support the use of SSRI and SNRI antidepressants during pregnancy, there is less data regarding other classes of antidepressants. Although we less commonly use mirtazapine in pregnancy, several [...]
Ketamine and Pregnancy: Taking a Look at the Practices of Ketamine Clinics
With ketamine and esketamine increasingly used to treat depression, especially in women of reproductive age, this study reveals important gaps in care, including inconsistencies in pregnancy testing, informed consent, and contraception practices among ketamine clinics in the United States.Â
New Research from the CWMH: Risk of Major Malformations in Infants with Prenatal Exposure to Benzodiazepines
Data from an ongoing pregnancy registry offers reassurance that benzodiazepines do not appear to have major teratogenic effects.
Is it Safe to Use Atomoxetine (Strattera) During Pregnancy?
Based on this large cohort study including 990 pregnancies with first trimester exposure to atomoxetine, the researchers observed no increase in major congenital malformations overall and no statistically increased risk estimates for cardiac or limb malformations.
New Research from the CWMH: Preliminary Data on the Reproductive Safety of Buspirone (BuSpar)
Although a small sample, no major malformations were observed in a prospectively followed cohort of women with first trimester exposure to buspirone.