Pregnancy as a Time of Increased Vulnerability to Trauma, Persistent Changes in Immune Function
Exposure to interpersonal violence during both early childhood and pregnancy may pose a long-term risk for worse health outcomes.
In Women with Opioid Use Disorder, Treatment Initiated During Pregnancy May Improve Postpartum Outcomes
This study demonstrates higher rates of treatment continuation in postpartum women with opioid use disorders if medication treatment (methadone or buprenorphine) is initiated early and maintained throughout pregnancy.
Essential Reads: Strategies for the Prevention of Postpartum Depression
Postpartum depression (PPD) is a relatively common problem, affecting between 10% and 15% of women after delivery. Although it is difficult to reliably predict which women in the general population will experience postpartum depression, it [...]
High Levels of Distress in Pregnant and Postpartum Women During the Pandemic
This international survey demonstrates that pregnant and postpartum women are more likely to report elevated symptoms of depression, anxiety, and post-traumatic stress than others in the general population in the context of the COVID-19 pandemic.
Caffeine and Pregnancy: How Much is Safe?
Many women ask about the safety of drinking caffeinated beverages during pregnancy. A recent study looked at this question, analyzing data from the NICHD Fetal Growth Studies–Singletons, which included a group of 2,055 nonsmoking women at low risk for fetal growth problems. Caffeine consumption was evaluated using plasma concentrations of caffeine and paraxanthine (a metabolite of caffeine) and self-reported caffeinated beverage consumption at 10 to 13 weeks gestation.
Essential Reads: Bupropion (Wellbutrin) and Risk for Major Malformations
Bupropion is commonly used to treat depression, and is also prescribed to support smoking cessation. Early data on bupropion-exposure during pregnancy raised concern for a possible increase in risk of malformations of the heart and large blood vessels in bupropion-exposed infants. Subsequent data from bupropion pregnancy registries has been reassuring, however, and do not demonstrate an overall increase in risk of cardiac defects following first trimester bupropion exposure. Although the overall risk of cardiac defects was not increased, the distribution of specific defects in these registries was unexpected in some ways. For example, the GlaxoSmithKline Bupropion Pregnancy Registry included two cases of coarctation of the aorta out of the 675 bupropion-exposed infants, compared to the rate of 6 cases per 10,000 births in the general population.
COVID Vaccination in Pregnant and Lactating Mothers, Transfer of Antibodies to the Baby
While the risk of severe COVID in pregnant women is relatively low, pregnant women with severe COVID experience worse outcomes. Some of our perinatal patients can’t wait to get a COVID-19 vaccine, some of our [...]
Essential Reads: Should Lithium Dose Be Reduced Prior to Delivery?
The dosing of lithium presents certain challenges during pregnancy. During pregnancy, there is a physiologic increase in the glomerular filtration rate (GFR), which is a measure of how quickly the kidney clears renally excreted compounds, [...]
New Research from the CWMH: No Increase in Major Malformations in Children Prenatally Exposed to Aripiprazole
Despite the increasing use of the newer atypical or second-generation antipsychotic agents to treat a spectrum of psychiatric disorders, including psychotic disorders, bipolar disorder, major depression, PTSD and other anxiety disorders, we have relatively little [...]
Essential Reads: Innovative Methods for Addressing Substance Abuse During Pregnancy
While the use of alcohol and tobacco during pregnancy is falling, the use of cannabis and opioids is increasing. The American College of Obstetricians and Gynecologists now recommends universal screening for substance use to be [...]