Mass General Hospital

Harvard Medical School

Tag Archives | pregnancy

Lamotrigine and Pregnancy: Meta-Analysis Shows No Increase in Risk for Malformations

  Maintenance treatment with a mood stabilizer during pregnancy can significantly reduce the risk of relapse in women with bipolar disorder; however, many of the mood stabilizers commonly used in this setting, including lithium and valproic acid, carry some degree of teratogenic risk. In contrast, lamotrigine (Lamictal) appears to be a much safer option for […]

Continue Reading · 0

In Brief: Beta Blockers and Pregnancy, No Observed Increase in Risk of Malformations

Beta blockers are the most commonly used class of medication for treating cardiac conditions in pregnant women.  They are also effective for the treatment of anxiety symptoms, most commonly performance anxiety. According to a report published online in JAMA Internal Medicine, maternal use of beta-blockers during pregnancy (n=4847) was associated with increased risk for fetal […]

Continue Reading · 0

More Data on Pregabalin (Lyrica) and Pregnancy

Pregabalin (marketed in the US as Lyrica) is approved by the US Food and Drug Administration for the treatment of epilepsy, fibromyalgia, and neuropathic pain.  It is also used off-label to treat psychiatric disorders, most commonly generalized anxiety disorder.  While it is not used as frequently as other anti-epileptic drugs, we do occasionally see women […]

Continue Reading · 0

Is BDNF a Biomarker for Depression During Pregnancy and the Postpartum Period?

Brain-derived neurotrophic factor (BDNF) is a growth factor which acts on neurons in both the central and peripheral nervous systems, promoting the survival of neurons and promoting the growth and differentiation of new neurons and synapses.  In the brain, it is most active in the hippocampus, cortex, and basal forebrain—areas important  to learning, memory, and […]

Continue Reading · 0

USPSTF Emphasizes Periconceptual Use of Folic Acid to Prevent Birth Defects

Neural tube defects are among the most common major congenital anomalies in the United States and are associated with significant disability and death.  The risk of neural tube defects can be prevented with daily folic acid supplementation in the periconceptional period.  However, most women do not receive the recommended daily intake of folate.  January 5–11 […]

Continue Reading · 0
Credit: Pregnant Woman from Wikimedia Commons

The 50-year Quest for Better Pregnancy Data

The following post was first published in OB/GYN News. Please see our OB/GYN News archives here. Publish date: November 1, 2016 By: Gerald G. Briggs, BPharm, FCCP, Christina Chambers, PhD, MPH, Lee S. Cohen, MD, & Gideon Koren, MD Editor’s note: As Ob.Gyn. News celebrates its 50th anniversary, we wanted to know how far the medical community has come in identifying and […]

Continue Reading · 0

MCPAP for Moms: Exploring New Strategies for Providing Care to Women with Perinatal Depression

We are clearly making big strides in terms of increasing public awareness of perinatal mood and anxiety disorders, but we still have a long way to go when it comes to providing access to mental health professionals with expertise in this area.  We have demonstrated that screening for perinatal depression can be carried out successfully […]

Continue Reading · 0

Risk of Neonatal Morbidity in Infants Exposed to SSRIs

A few days ago, an article was published in the journal Pediatrics on neonatal morbidity observed in children exposed to antidepressants.  Although this article is likely to find its way into the headlines, it is important to note that the information presented here is nothing new.  Similar to previous studies, the Pediatrics study reveals higher […]

Continue Reading · 0

Prenatal Exposure to Levetiracetam and Topiramate: No Evidence of Cognitive Deficits

Many of the newer antiepileptic drugs (AEDs) have uses beyond the treatment of epilepsy.  Topiramate (marketed as a Topamax), in addition to its use for the treatment of epilepsy, is now being prescribed to reproductive aged women for a broad spectrum of indications, including migraine headaches, weight control, and mood stabilization.  Limited information is available […]

Continue Reading · 0
By Ragesoss - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=4544244

Preliminary Study: Folic Acid Reduces Risk for Autism in Kids Prenatally Exposed to Antiepileptic Drugs

Several studies have observed that fetal exposure to the antiepileptic drug (AED), valproic acid (Depakote), may significantly increase the risk of having a child with an autism spectrum disorder.  In contrast, exposures to other AEDs, including carbamazepine (Tegretol), oxcarbazepine (Trileptal), and lamotrigine (Lamictal), have not been associated with an increased risk of autism spectrum disorder […]

Continue Reading · 0