Neurodevelopmental Outcomes in Children with Prenatal Exposure to Antiepileptic Drugs: A Systematic Review
A systematic review examines neurodevelopmental outcomes in children prenatally exposed to antiepileptic drugs.
A systematic review examines neurodevelopmental outcomes in children prenatally exposed to antiepileptic drugs.
Prenatal exposure to prescription stimulants was not associated with an increased risk of neurodevelopmental disorders in exposed children.
Prenatal exposure to ADHD medications, mostly methylphenidate, was not associated with an increased risk of neurodevelopmental disorders or growth restriction in exposed children.
Maternal SSRI use during pregnancy may be associated with altered brain development in children; however, this study cannot fully rule out contributions of confounding genetic and enviromental factors.
Data from an ongoing pregnancy registry offers reassurance that benzodiazepines do not appear to have major teratogenic effects.
Functional MRI revealed no differences in brain structure of white matter integrity in lithium-exposed versus non-lithium-exposed children born to mothers with bipolar spectrum disorder.
Two studies - one using neuropsychological assessments, another examining performance on standardized testing - show no association between prenatal antipsychotic exposure and neurodevelopmental outcomes.
Consistent with other studies, including a large meta-analysis, this study indicates no increased risk of ADHD in offspring following prenatal exposure to antidepressants.
Data from a Nordic register-based study observed a significant increase in risk for autism spectrum disorder and intellectual disability in children with prenatal exposure to topiramate.
The largest study to date observes no increase in risk of autism or ADHD in children with prenatal exposure to benzodiazepines.