Over the last few years we have heard a great deal about neurosteroids, also known as neuroactive steroids. This class of compounds are steroid hormones produced in the brain and endocrine tissues which can [...]
Patients and clinicians may not be fully aware that women are at increased risk for depression during the menopausal transition. The U.S. Preventive Services Task Force (USPSTF) recommends that clinicians screen all adults for [...]
As women transition into the menopause, they experience a constellation of symptoms including vasomotor symptoms (hot flashes and night sweats), sleep disruption, problems with sexual functioning, and cognitive impairment. Women may also be more [...]
Stimulation of NKB-neurokinin 3 receptor (NK3R) signalling can induce hot flashes
A trial of melatonin supplementation may be considered in perimenopausal women with sleep disturbance.
Recent studies suggest that the burden of menopausal symptoms is greater than generally perceived. About 80% of women experience vasomotor symptoms (VMS) – hot flashes and night sweats — as they transition into the [...]
Women are twice as likely as men to have major depressive disorder (MDD) during their lifetimes, and women are particularly at risk during the menopausal transition (including perimenopause and early menopause), which can last [...]
In 2008, the National Institutes of Health funded the Menopause Strategies: Finding Lasting Answers for Symptoms and Health or MSFlash clinical trials network. The primary goal of MSFlash has been to find and test [...]
While earlier observational studies suggested that hormone treatment may improve cognitive functioning in peri- and postmenopausal women, studies from the Women’s Health Initiative (WHI) demonstrated that estrogen replacement therapy started in postmenopausal women (65 [...]
About 80% of women experience vasomotor symptoms (VMS) – hot flashes and night sweats — as they transition into the menopause phase. For most, the symptoms are manageable, but for a sizeable subset of midlife [...]
