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Tag Archives | menopausal symptoms

Neurokinin-3 Receptor Antagonists: A Novel Approach to the Treatment of Menopausal Symptoms

Over the last few years, we have seen a number of articles suggesting that the burden of menopausal symptoms is probably greater than generally perceived.  About 80% of women experience vasomotor symptoms (VMS) – hot flashes and night sweats — as they transition into the menopause.  For most, the symptoms are manageable, but for a […]

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What Exactly Causes Hot Flashes in Menopausal Women? Researchers Look at Neurokinin B

Perimenopausal vasomotor symptoms are triggered by a fall in circulating levels of estrogen and other sex steroids. It has been hypothesized that thermoregulatory centres in the hypothalamus play a crucial role in mediating the hot flash response. However, exactly how do hormonal changes bring about these changes in the hypothalamus?  If we could understand this […]

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In Brief: Telephone-Based CBT for Menopause-Related Insomnia

Peri- and postmenopausal women frequently complain of insomnia or poor sleep quality. Sleep disturbance is often attributed to nocturnal hot flashes.  While nocturnal hot flushes may be the cause of sleep disruption in many peri- and postmenopausal women, many of these women have an underlying primary sleep disorder, like restless leg syndrome or sleep apnea. […]

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Photo by Christoph Lehmann https://www.flickr.com/photos/grooovy_easy/5255389744/in/photolist-91pfh1-5oVsER-pFpnRy-ec2MCd-gF9N97-5b3Vne-4NFhyn-8iQxd7-dUwWK-99SzT7-oEz9b9-6Bd2RD-64wPBn-bRpiQ6-6pQf1X-6CCqez-a7FBLH-9hhcsM-hhqhvC-Hx3Lu-w8y2T4-qpERyX-5FKSzJ-8MiyXg-2hvEdW-RBDAe-qxxAD4-4PRiP1-nE2Gaf-iGVY57-4VahiX-9DGHg9-r2EXfL-3hshNC-gGgjkR-buckND-jBwuQM-tQZcDc-qUzYP5-82899z-tyamDh-Hx9Ur-ciRYs5-jjzkxT-fp455D-2JrfTi-hy318h-5mZDc7-q61Z2D-dywyCa

Nonhormonal Management of Menopausal Vasomotor Symptoms: 2015 NAMS Position Statement

Since the Women’s Health Initiative (WHI) reported that the risks of menopausal hormone replacement therapy (HRT) outweighed its benefits, there has been a significant reduction in the use of HRT.  However, recent studies have suggested that many peri- and postmenopausal women experience significant symptoms for many years and that these symptoms have a marked impact […]

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In Brief: Menopausal Symptoms More Severe in Sedentary Women

According to a recent study article published online in Menopause, having a sedentary lifestyle significantly affects the severity of perimenopausal symptoms.  This study included more than 6000 women aged 40 to 59 years who received care at urban health clinics across 11 Latin American countries. Women who exercised fewer than three times per week reported more severe menopause symptoms than […]

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Photo by Christoph Lehmann https://www.flickr.com/photos/grooovy_easy/5255389744/in/photolist-91pfh1-5oVsER-pFpnRy-ec2MCd-gF9N97-5b3Vne-4NFhyn-8iQxd7-dUwWK-99SzT7-oEz9b9-6Bd2RD-64wPBn-bRpiQ6-6pQf1X-6CCqez-a7FBLH-9hhcsM-hhqhvC-Hx3Lu-w8y2T4-qpERyX-5FKSzJ-8MiyXg-2hvEdW-RBDAe-qxxAD4-4PRiP1-nE2Gaf-iGVY57-4VahiX-9DGHg9-r2EXfL-3hshNC-gGgjkR-buckND-jBwuQM-tQZcDc-qUzYP5-82899z-tyamDh-Hx9Ur-ciRYs5-jjzkxT-fp455D-2JrfTi-hy318h-5mZDc7-q61Z2D-dywyCa

NAMS Urges Prescribers to Avoid Bioidentical Hormones

According to data presented at the annual meeting of the North American Menopause Society (NAMS)  in Las Vega, a growing number of perimenopausal women are asking their doctors for compounded or bioidentical hormones.  Although bioidentical hormones are touted as being “natural”, they, like synthetic hormones, are manufactured in the laboratory.   Bioidentical hormones are chemically identical […]

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In Brief: Venlafaxine as Effective as Low-Dose Estradiol for Menopausal Sleep Symptoms

Which treatment is best for managing menopausal sleep problems? We tend to think of estrogen replacement therapy as being the best option for all menopausal symptoms; however, there are other options for managing menopausal symptoms, including serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors, and gabapentin. A recent study compares low-dose estradiol and low-dose venlafaxine for the […]

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Photo by Christoph Lehmann https://www.flickr.com/photos/grooovy_easy/5255389744/in/photolist-91pfh1-5oVsER-pFpnRy-ec2MCd-gF9N97-5b3Vne-4NFhyn-8iQxd7-dUwWK-99SzT7-oEz9b9-6Bd2RD-64wPBn-bRpiQ6-6pQf1X-6CCqez-a7FBLH-9hhcsM-hhqhvC-Hx3Lu-w8y2T4-qpERyX-5FKSzJ-8MiyXg-2hvEdW-RBDAe-qxxAD4-4PRiP1-nE2Gaf-iGVY57-4VahiX-9DGHg9-r2EXfL-3hshNC-gGgjkR-buckND-jBwuQM-tQZcDc-qUzYP5-82899z-tyamDh-Hx9Ur-ciRYs5-jjzkxT-fp455D-2JrfTi-hy318h-5mZDc7-q61Z2D-dywyCa

Proving the Estrogen Withdrawal Hypothesis of Perimenopausal Depression

Because women appear to be at increased risk for new onset and recurrent depression as they transition into the menopause, it has been hypothesized that declining ovarian function — or estrogen “withdrawal” — may trigger depressive symptoms in some women.  While this is a very reasonable and totally plausible hypothesis, no studies have formally tested […]

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Photo by Christoph Lehmann https://www.flickr.com/photos/grooovy_easy/5255389744/in/photolist-91pfh1-5oVsER-pFpnRy-ec2MCd-gF9N97-5b3Vne-4NFhyn-8iQxd7-dUwWK-99SzT7-oEz9b9-6Bd2RD-64wPBn-bRpiQ6-6pQf1X-6CCqez-a7FBLH-9hhcsM-hhqhvC-Hx3Lu-w8y2T4-qpERyX-5FKSzJ-8MiyXg-2hvEdW-RBDAe-qxxAD4-4PRiP1-nE2Gaf-iGVY57-4VahiX-9DGHg9-r2EXfL-3hshNC-gGgjkR-buckND-jBwuQM-tQZcDc-qUzYP5-82899z-tyamDh-Hx9Ur-ciRYs5-jjzkxT-fp455D-2JrfTi-hy318h-5mZDc7-q61Z2D-dywyCa

Research Study: Vortioxetine for Perimenopausal and Postmenopausal Women

The menopausal transition is a difficult time for many women.  There is an increased risk of depressive episodes during this transition in the reproductive lifecycle, and the majority of women will experience symptoms related to perimenopause (such as hot flashes, sleep disturbance, and cognitive complaints). Vortioxetine (brand name Brintellix) is a novel antidepressant that was […]

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New Research from the CWMH: Armodafinil for Menopause-Related Fatigue

Several recent articles indicate that the burden of menopausal symptoms is greater than generally perceived.  About 80% of women experience vasomotor symptoms (VMS) – hot flashes and night sweats — as they transition into the menopause phase.  For most, the symptoms are manageable, but for a sizeable subset of midlife women, these symptoms can negatively […]

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