We have received many emails and calls from colleagues and patients regarding the recent article on the safety of SSRI use during pregnancy published in the New York Times. In this article, health writer Roni Caryn Rabin, detailed the risks associated with the use of antidepressants during pregnancy.
Benzodiazepines and non-benzodiazepine hypnotics are commonly used during pregnancy. However, there data regarding the reproductive safety of these agents has been somewhat mixed. Although initial reports suggested that there may be an increased risk of cleft lip and palate, more recent reports have shown no association between exposure to benzodiazepines and risk for cleft lip or palate. A new study shows no increase in the overall risk of malformations among children exposed to benzodiazepines.
In this study 62 women hospitalized for high-risk obstetrical complications completed the Edinburgh Postnatal Depression Scale (EPDS), Generalized Anxiety Disorder 7-item scale (GAD-7), and Short-Form 12 (SF-12) weekly until delivery or discharge and once after [...]
About 75% of peri- and postmenopausal women have vasomotor symptoms, such as hot flashes and night sweats; however, some women experience more distress or "bother" in response to these symptoms. A new research study suggests that certain personality traits may affect how women experience these uncomfortable symptoms.
Pregnancy is a time of risk for women with histories of major depression. In a study where 201 women with histories of recurrent depression were followed prospectively through pregnancy, 43% experienced a relapse of major depression during pregnancy. Relapse rates were highest in the group of women who elected to discontinue antidepressant treatment proximate to conception (68% as compared to 26% in the group of women who maintained antidepressant treatment).
A recent study from researchers at the University of North Carolina reports that the children of depressed mothers treated with selective serotonin reuptake inhibitors (SSRIs) during pregnancy were more likely to develop Chiari type 1 malformations than were the children of mothers with no history of depression.
Many studies have assessed the risk of depression in the mothers of infants, but fewer studies have focused on the risk of depression in the mothers of older children. A recent study published in BJOG [...]
A recent study suggests that physical exercise during pregnancy may reduce depressive symptoms. This study from Spain included 184 healthy pregnant women (31.37 ± 3.62 years). Women randomized to the exercise group (EG) participated in a supervised exercise program consisting of three, 55- to 60-min sessions per week throughout pregnancy. A total of 167 pregnant women were analyzed; 90 in the exercise group and 77 in the control group. Significant differences were found between the two groups at the end of the study in terms of level of depressive symptoms as measured by the Center for Epidemiologic Studies Depression Scale (CES-D): 7.67 ± 6.30 in the exercise group vs. 11.34 ± 9.74 in the control group (p = .005). The percentage of women who were depressed was also lower in the exercise group (12.2%) as compared to the control group (24.7%).
It is estimated that suicide accounts for about 10% of all maternal deaths. While we have a fair amount of information to help us predict which women are at risk for depression during pregnancy and [...]
SSRIs were not associated with an increased risk of miscarriage.
