birth defect

New Research from the CWMH: Prenatal Exposure to Atypical Antipsychotics Does Not Increase Risk of Malformations

The use of the newer “atypical” or second-generation antipsychotic agents continues to increase.  These medications are used to treat a spectrum of psychiatric disorders, including schizophrenia, bipolar disorder, major depression, PTSD and anxiety disorders.  Although [...]

Clinical Update: Use of Topiramate (Topamax) During Pregnancy

Topiramate (TPM, marketed as Topamax) is an antiepileptic drug which is also used for migraine prophylaxis, weight loss, and, less commonly, as a mood stabilizer.  Over the last few years we have seen several studies suggesting an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy.  You can read more about those studies here:

Avoid Valproic Acid in Women of Reproductive Age

The European Medicine Agency (EMA)'s Pharmacovigilance and Risk Assessment Committee recently recommended strengthening the restrictions on the use of valproic acid in women of reproductive age.  Over the last few years, we have seen a host of articles documenting the deleterious effects of valproic acid on the developing fetus: