Topiramate exposure in early pregnancy is linked to higher rates of major malformations and more specifically to increased risk of oral clefts, with risk rising at higher doses.
Prenatal exposure to valproate is linked to increased risk of autism spectrum disorder, ADHD, lower IQ, and intellectual disability, especially at higher doses.
This meta-analysis is reassuring regarding risk for malformations in children exposed prenatally to oxcarbazepine; however, we still need more data to fully assess reproductive safety.
Data from a Nordic register-based study observed a significant increase in risk for autism spectrum disorder and intellectual disability in children with prenatal exposure to topiramate.
These findings are encouraging and suggest that the newer AEDs, specifically lamotrigine and levetiracetam, are not associated with worse neurodevelopmental outcomes.
Lamotrigine is detected in the breast milk and in the serum of the nursing infant; however, the risk of adverse events is very low.
Multiple studies have associated first trimester exposure to topiramate with increased risk of oral clefts.
We have really enjoyed our weekly virtual rounds. It’s been a great opportunity to meet other perinatal psychiatrists in the community, and discussions with new people always brings up interesting clinical questions. Last week [...]
Previous studies have shown that children exposed to antiepileptic drugs (AEDs) during pregnancy may be at increased risk for neurodevelopmental disorders. Â In a recent population-based cohort study from Denmark, researchers examined the prevalence of [...]
EURAP is an international registry for antiepileptic drugs and pregnancy. Â At its inception in 1999, it included only European countries but EURAP has grown and now includes 42 countries from Europe, Australia, Asia, South America. [...]
