Treatment - MGH Center for Women's Mental Health

Duloxetine for the Treatment of Menopausal Symptoms and Mood in Postmenopausal Women

Depression is common in postmenopausal women suffering from menopausal vasomotor symptoms (hot flushes, night sweats) and insomnia. While estrogen replacement therapy may alleviate these symptoms and may also have a positive impact on mood, the use of estrogen has declined over recent years. There has been great interest in finding alternative strategies for the management of menopausal symptoms, and recent data suggest that selective serotonin reuptake inhibitor antidepressants (SSRIs) and the serotonin norepinephrine reuptake inhibitor (SNRI), venlafaxine, may be effective for the treatment of depression and vasomotor symptoms in peri- and postmenopausal women. In a study presented at the annual meeting of the American Psychiatric Association, Dr. Hadine Joffe and her colleagues at the Center of Women’s Mental Health presented data on the use of duloxetine (Cymbalta), a new SNRI, for the treatment of mood, vasomotor symptoms, and insomnia in postmenopausal women.

By MGH Center for Women's Mental Health|2015-07-28T10:00:40-04:00July 30th, 2006|Depressive Disorders, Medication, Menopausal Symptoms, Treatment, Vasomotor Symptoms|Comments Off

Escitalopram for Menopause-Related Depression and Vasomotor Symptoms

Every year more than 1.7 million women in the United States enter into menopause. During this time of hormonal fluctuations it is typical for women to experience hot flashes, night sweats and sleep disturbance. More recently, studies have identified an association between menopausal transition and an increased risk for developing depressive symptoms (Harlow et al., 2003; Freeman et al., 2004). It is not clear how physicians and patients should deal with menopause-related physical and emotional symptoms. While hormone therapy effectively treats insomnia and hot flashes, the results have been mixed in treating mood and anxiety symptoms. Moreover, the safety of long-term use of hormone therapy is not known.

By MGH Center for Women's Mental Health|2015-07-23T14:19:33-04:00December 30th, 2005|Depressive Disorders, Medication, Menopausal Symptoms, Treatment, Vasomotor Symptoms|Comments Off

Oral Contraceptives for the Treatment of Premenstrual Mood Symptoms in Women with Depression

About 3-5% of women of reproductive age suffer from premenstrual dysphoric disorder (PMDD), where they experience depressive symptoms, anxiety or irritability during the last one to two weeks (the premenstrual phase) of their menstrual cycle. In addition, many women who suffer from depression, including those who have been effectively treated with an antidepressant, report worsening of their depressive symptoms during the premenstrual phase of the menstrual cycle. Although this may be a consequence of sensitivity to fluctuating hormone levels, little is known about the efficacy of hormonal interventions, including oral contraceptives (OCPs), in the treatment of premenstrual worsening of depressive symptoms.

By MGH Center for Women's Mental Health|2016-03-28T13:51:33-04:00June 14th, 2005|Depressive Disorders, Hormone Therapy, PMS & PMDD, Treatment|Comments Off

Acupuncture for Depression During Pregnancy

Depression during pregnancy is relatively common, affecting about 10 to 15% of women. While there is a growing body of literature supporting the reproductive safety of certain antidepressants, our understanding of how these psychotropic medications affect the developing fetus remains incomplete. For this reason, many women and their physicians would prefer to avoid the use of antidepressants during pregnancy; thus, there is a clear need for effective non-pharmacologic treatments for women who suffer from depression during pregnancy. In a recent study from Dr. Rachel Manber and her colleagues at Stanford University, the use of acupuncture is assessed in a group of pregnant depressed women.

By MGH Center for Women's Mental Health|2015-07-21T11:46:39-04:00February 14th, 2005|Alternative & Complementary, Depressive Disorders, Psychiatric Disorders During Pregnancy, Treatment|Comments Off

Venlafaxine (Effexor) for Postmenopausal Hot Flushes

During the menopausal transition, up to 85% of women experience vasomotor symptoms of hot flushes and night sweats. For many women, hot flushes may be severe; they can interfere with work and other daily activities and affect sleep quality. Hot flushes may be associated with fatigue, poor concentration, and depression. Given the recent data from the Women's Health Initiative regarding the risks associated with long-term use of estrogen, many peri- and post-menopausal women are understandably reluctant to take menopausal hormone therapy for the treatment of hot flushes, despite its proven efficacy. Given these concerns, there is a clear need for alternative non-hormonal therapies for the treatment of hot flushes and other menopause-related symptoms.

By MGH Center for Women's Mental Health|2015-07-21T11:41:35-04:00January 18th, 2005|Medication, Menopausal Symptoms, Treatment|Comments Off

Paroxetine and Cognitive-Behavioral Therapy (CBT) for the Treatment of Postpartum Depression (PPD)

Postpartum depression (PPD) is relatively common, occurring in about 10 to 15% of women after delivery. Non-pharmacologic interventions, including interpersonal psychotherapy, have been shown to be effective for the treatment of PPD. In addition, several reports have documented the efficacy of selective serotonin reuptake inhibitors (SSRIs) and the serotonin norepinephrine reuptake inhibitor venlafaxine (Effexor). In a recent report, Misri and colleagues have evaluated whether the addition of Cognitive-Behavioral Therapy (CBT) to standard antidepressant treatment improves outcomes in women with postpartum depression and co-morbid anxiety.

By MGH Center for Women's Mental Health|2015-07-21T11:37:31-04:00September 20th, 2004|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Psychotherapy, Treatment|Comments Off

Light Therapy for Depression During Pregnancy

Depression during pregnancy (antenatal depression) is relatively common, affecting about 10% of women. While there is a growing body of literature supporting the reproductive safety of certain antidepressants, our understanding of how these psychotropic medications affect the developing fetus remains incomplete. For this reason, antidepressants are typically avoided during pregnancy; thus, there is a clear need for effective non-pharmacologic treatments for women at high risk for antenatal depression.

By MGH Center for Women's Mental Health|2015-07-20T11:00:36-04:00June 23rd, 2002|Alternative & Complementary, Depressive Disorders, Psychiatric Disorders During Pregnancy, Treatment|Comments Off

Agnus Castus Fruit Extract as a Treatment for Premenstrual Syndrome

During the period before menstruation, many women report experiencing psychological and physical symptoms collectively referred to as premenstrual syndrome (PMS). The fruits, leaves and flowers of Vitex agnus castus (the Chaste Tree) have traditionally been used to relieve these symptoms. While the mode of action is not clear, the effects of the plant seem to mimic those of the corpus luteum, stimulating the production of lutenizing hormone, thereby increasing progesterone production. Schellenberg and colleagues recently studied the effects of agnus castus fruit in women with premenstrual syndrome.

By MGH Center for Women's Mental Health|2015-07-20T11:28:59-04:00May 20th, 2002|Alternative & Complementary, PMS & PMDD, Treatment|Comments Off

Venlafaxine for Postpartum Depression

Postpartum depression (PPD) is relatively common, occurring in about 10 to 15% of women after delivery. Several reports have documented the efficacy of selective serotonin reuptake inhibitors (SSRIs) sertraline, fluoxetine, and fluvoxamine for the treatment of this disorder. In a recent report, Cohen and colleagues have demonstrated the efficacy of venlafaxine for the treatment of PPD.

By MGH Center for Women's Mental Health|2016-03-28T13:24:00-04:00February 20th, 2002|Medication, Postpartum Depression, Postpartum Psychiatric Disorders, Treatment|Comments Off

Selecting an Antidepressant During Pregnancy

Most women and their doctors try to avoid using medications during pregnancy. Of greatest concern is that a medication used during pregnancy may in some way harm the developing fetus or, at the very worst, cause a birth defect. But what happens when a pregnant woman needs to take a medication?

By MGH Center for Women's Mental Health|2015-07-20T10:15:46-04:00May 6th, 2001|Anxiety Disorders, Child Outcomes, Depressive Disorders, Medication, Pregnancy & Medications, Psychiatric Disorders During Pregnancy, Risk of Malformations, Treatment|Comments Off