Risk of Malformations

More Data on Pregabalin (Lyrica) and Pregnancy

Pregabalin (marketed in the US as Lyrica) is approved by the US Food and Drug Administration for the treatment of epilepsy, fibromyalgia, and neuropathic pain.  It is also used off-label to treat psychiatric disorders, most [...]

By |2017-05-02T15:49:43-04:00May 2nd, 2017|Anti-Anxiety Medications, Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on More Data on Pregabalin (Lyrica) and Pregnancy

USPSTF Emphasizes Periconceptual Use of Folic Acid to Prevent Birth Defects

Neural tube defects are among the most common major congenital anomalies in the United States and are associated with significant disability and death.  The risk of neural tube defects can be prevented with daily folic [...]

By |2017-01-13T10:34:56-04:00January 10th, 2017|Psychiatric Disorders During Pregnancy, Risk of Malformations|Comments Off on USPSTF Emphasizes Periconceptual Use of Folic Acid to Prevent Birth Defects

Prenatal Antiepileptic Exposure Increases Risk for Malformations: Does High-Dose Folic Acid Reduce Risk?

The CDC, the U.S. Public Health Service, and the American College of Obstetricians and Gynecologists (ACOG) all recommend that every woman of reproductive age get 400 micrograms (400 mcg) or 0.4 milligrams of folic acid [...]

By |2016-10-24T09:32:36-04:00October 24th, 2016|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Prenatal Antiepileptic Exposure Increases Risk for Malformations: Does High-Dose Folic Acid Reduce Risk?

New Research from the CWMH: Prenatal Exposure to Atypical Antipsychotics Does Not Increase Risk of Malformations

The use of the newer “atypical” or second-generation antipsychotic agents continues to increase.  These medications are used to treat a spectrum of psychiatric disorders, including schizophrenia, bipolar disorder, major depression, PTSD and anxiety disorders.  Although [...]

By |2020-11-26T08:33:55-04:00August 23rd, 2016|Antipsychotic Medications, Outcomes, Pregnancy & Medications, Research at CWMH, Risk of Malformations|Comments Off on New Research from the CWMH: Prenatal Exposure to Atypical Antipsychotics Does Not Increase Risk of Malformations

You Asked: What Dose of Folic Acid for Pregnant Women Taking Lamotrigine (Lamictal)?

In our community of perinatal psychiatrists, we have recently seen many questions regarding the use of folic acid supplementation in women taking lamotrigine (Lamictal).  While all recognize that all women of childbearing age should receive [...]

By |2025-06-26T09:07:03-04:00July 28th, 2016|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on You Asked: What Dose of Folic Acid for Pregnant Women Taking Lamotrigine (Lamictal)?

New Research from the CWMH: Evaluating the Risk of Major Malformations in Children Prenatally Exposed to Atypical Antipsychotics

Despite the increasing use of the newer “atypical” or second-generation antipsychotic agents to treat a spectrum of psychiatric disorders, including schizophrenia, bipolar disorder, major depression, PTSD and other anxiety disorders, we have relatively little data [...]

By |2016-07-12T15:30:24-04:00July 11th, 2016|Antipsychotic Medications, Outcomes, Pregnancy & Medications, Research at CWMH, Risk of Malformations|Comments Off on New Research from the CWMH: Evaluating the Risk of Major Malformations in Children Prenatally Exposed to Atypical Antipsychotics

Should We Just Say No? Valproic Acid and Women of Childbearing Age

  There have long been concerns regarding the use of the anticonvulsant valproate (Depakote) during pregnancy.  First trimester use of valproate has been associated with a 3-5% risk of neural tube defects, as well as [...]

By |2016-06-16T23:14:25-04:00June 16th, 2016|Anti-Epileptic Drugs, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Should We Just Say No? Valproic Acid and Women of Childbearing Age

Methylphenidate and Pregnancy: No Increase in Risk of Malformations

For women with mild to moderate attention-deficit/hyperactivity disorder (ADHD) symptoms, we typically recommend discontinuing medication and switching to a nonpharmacologic intervention.  Although these women might experience some decrease in their level of functioning, they are [...]

By |2016-06-06T07:36:20-04:00June 6th, 2016|ADHD Medications, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on Methylphenidate and Pregnancy: No Increase in Risk of Malformations

New Research from the CWMH: Evaluating the Risk of Major Malformations in Children Prenatally Exposed to Atypical Antipsychotics

Despite the increasing use of the newer “atypical” or second-generation antipsychotic agents to treat a spectrum of psychiatric disorders, including schizophrenia, bipolar disorder, major depression, PTSD and other anxiety disorders, we have relatively little data [...]

By |2021-03-29T10:51:11-04:00June 3rd, 2016|Antipsychotic Medications, Outcomes, Pregnancy & Medications, Research at CWMH, Risk of Malformations|Comments Off on New Research from the CWMH: Evaluating the Risk of Major Malformations in Children Prenatally Exposed to Atypical Antipsychotics

SSRIs and Pregnancy: No Risk of Cardiovascular Malformations According to UK Study

Over the last few years, several studies have suggested an increased risk of certain types of cardiovascular malformations in children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports suggested a link [...]

By |2016-05-20T07:53:13-04:00May 24th, 2016|Antidepressants, Outcomes, Pregnancy & Medications, Risk of Malformations|Comments Off on SSRIs and Pregnancy: No Risk of Cardiovascular Malformations According to UK Study
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