New Research from the CWMH: No Increase in Major Malformations in Children with Prenatal Exposure to Olanzapine
No major malformations were associated with olanzapine exposure during the first trimester of pregnancy.
Still Not Enough Data on the Reproductive Safety of Oxcarbazepine (Trileptal)
This meta-analysis is reassuring regarding risk for malformations in children exposed prenatally to oxcarbazepine; however, we still need more data to fully assess reproductive safety.
Suicidal Ideation Common in Women Seeking Treatment for Premenstrual Dysphoric Disorder
In this population seeking treatment for PMDD, suicidal ideation is very common, affecting about 40% of the women.
Essential Reads: What You Need to Know About Bioidentical Hormone Therapy for Menopausal Symptoms
While many peri- and post-menopausal women request bioidentical hormones, there is no data to suggest that bioidential hormones are safer or more effective than FDA-approved hormone replacement therapies.
Essential Reads: Folic Acid, Neural Tube Defects, and Congenital Heart Defects
Despite the unequivocal benefits of folic acid supplementation and recommendations urging all women of reproductive age to take folic acid supplements, preconceptual use of folic acid has not increased substantially.
Essential Reads: The Negative Impact of Prenatal Opioid Use on Fertility, Pregnancy, Neonatal Outcomes and Long-Term Developmental Outcomes
Prenatal opioid use is associated with increased maternal and infant mortality, prematurity, and poor neonatal outcomes.
Accumulating Data on the Reproductive Safety of Second-Generation Antipsychotics, But Still Not Enough
In a cohort of 351 children exposed to second generation antipsychotic during pregnancy, the risk of major congenital malformations did not differ from a comparison group of non-exposed children.
Neurodevelopmental Disorders in Children Exposed to Antipsychotic Medications During Pregnancy
Prenatal exposure to antipsychotic medications was not associated with increased risk of neurodevelopmental disorders in offspring.
Essential Reads: Duloxetine and Pregnancy (2021)
In this large study with over 1500 exposures, duloxetine exposure during the first trimester does not appear to increase risk of major malformations.
Essential Reads: Lamotrigine (Lamictal) and Breastfeeding (2021)
Lamotrigine is detected in the breast milk and in the serum of the nursing infant; however, the risk of adverse events is very low.