Antidepressant Effects on Motor Development Minimal, According to New Study
When we meet with women to discuss the reproductive safety of antidepressant medications, one of the most challenging and anxiety-provoking aspects of the consultation is the discussion we have regarding the long-term effects of prenatal antidepressant exposure on the child. Does antidepressant exposure during the earliest stages of brain development have lasting effects? Because studies assessing the effects of prenatal exposure to medication (or other environmental exposures) take decades to complete [...]
PMDD and Serotonin Reuptake Inhibitors: Does Symptom-Onset Dosing Work?
Multiple studies support the efficacy of serotonin reuptake inhibitors (SRIs) for the treatment of premenstrual dysphoric disorder (PMDD). In the initial studies, treatment was administered daily throughout the entire menstrual cycle. Researchers observed that for the treatment of PMDD, SRIs seemed to work more rapidly, taking effect within a few days of treatment initiation (as opposed to the 2-4 weeks needed for the treatment of major depression). Subsequent studies demonstrated that [...]
NAMS Urges Prescribers to Avoid Bioidentical Hormones
According to data presented at the annual meeting of the North American Menopause Society (NAMS) in Las Vega, a growing number of perimenopausal women are asking their doctors for compounded or bioidentical hormones. Although bioidentical hormones are touted as being “natural”, they, like synthetic hormones, are manufactured in the laboratory. Bioidentical hormones are chemically identical to the hormones produced by the human body, whereas synthetic hormones are structurally different yet are [...]
Exploring the Relationship Between Vitamin D, Inflammation, and Postpartum Depression
Vitamin D deficiency is more common than ever, and many experts are concerned that this deficiency may lead to a wide variety of health problems, including depression. The active form of vitamin D is produced by the human body as a byproduct of natural sun exposure; it is also found in certain foods, including some kinds of fish, egg yolks, and fortified dairy and grain products. Certain people – those with [...]
In Brief: Improving Cognition in Schizophrenia by Modulating the Estrogen Receptor
This article in Psychiatric Times reviews some interesting research which suggests that drugs which modulate the estrogen receptor may improve cognitive functioning in patients with schizophrenia. This is the first study to show that oral adjunctive treatment with raloxifene (120 mg per day) has beneficial effects on attention/processing speed and memory for both men and women with schizophrenia. Weickert TW, Weinberg D, Lenroot R, et al. Adjunctive raloxifene treatment improves attention [...]
New Research from the CWMH: Reassuring Data from the National Pregnancy Registry of Atypical Antipsychotics
Despite the increasing use of the newer “atypical” or second-generation antipsychotic agents to treat a spectrum of psychiatric disorders, including schizophrenia, bipolar disorder, major depression, PTSD and other anxiety disorders, we have relatively little data on the reproductive safety of these newer atypical agents. In response to this deficit, the National Pregnancy Registry for Atypical Antipsychotics was created to evaluate the safety of atypical antipsychotic medications taken by women during pregnancy. [...]