For PMDD, Does Symptom-Onset Dosing of an SSRI Work?
Symptom-onset dosing with a serotonin reuptake inhibitor for PMDD may have a greater impact on anger/irritability and relationship functioning than other symptoms.
Combining Tamoxifen with Antidepressants: What You Need to Know
An updated version of this post can be found HERE. Two thirds of all breast cancer tumors are known to have receptors that respond to hormones; that is they can grow in response to estrogen. [...]
SSRIs and Pregnancy: No Risk of Cardiovascular Malformations According to UK Study
Over the last few years, several studies have suggested an increased risk of certain types of cardiovascular malformations in children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports suggested a link [...]
PMDD and Serotonin Reuptake Inhibitors: Does Symptom-Onset Dosing Work?
Multiple studies support the efficacy of serotonin reuptake inhibitors (SRIs) for the treatment of premenstrual dysphoric disorder (PMDD). Â In the initial studies, treatment was administered daily throughout the entire menstrual cycle. Â Researchers observed that for [...]
Antidepressants and Pregnancy: Are Some SSRIs Safer Than Others?
 Over the last decade, numerous studies on the reproductive safety of selective serotonin reuptake inhibitors (SSRIs) have been published.  However, these studies, using different methodologies and studying different populations, have often yielded conflicting results. [...]
SSRIs and Pregnancy: No Increase in Risk of Malformations
Over the last few years, we have reported on several studies which have suggested an increased risk of certain types of cardiovascular malformations among children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The first reports [...]
SSRI Antidepressants Not Associated with Cardiovascular Defects
Over the last few years, we have reported on several studies which have suggested an increased risk of certain types of cardiovascular malformations among children exposed to selective serotonin reuptake inhibitors (SSRIs) during pregnancy. The [...]
SSRI Antidepressants and Male Fertility
Back in 2009, we reported on a study which demonstrated that paroxetine (Paxil) may affect sperm quality in men treated with this antidepressant. A new study reports a similar finding in men treated with sertraline [...]
Prevention of Postpartum Depression
Postpartum depression (PPD) is a relatively common problem, affecting between 10% and 15% of women after delivery. Although it is difficult to reliably predict which women in the general population will experience postpartum mood disturbance, it is possible to identify certain subgroups of women who are more vulnerable to postpartum affective illness. Women who have had one episode of postpartum depression have about a 50% chance of experiencing another episode of PPD after a subsequent pregnancy. The extent to which a history of depression (prior to pregnancy) influences risk is less clear, but some studies indicate that between 30% and 50% will suffer from recurrent depression during the postpartum period. Several investigators have recently explored the potential efficacy of prophylactic interventions in these populations of women at risk.